Sökning: "T cell selection"

Visar resultat 1 - 5 av 97 avhandlingar innehållade orden T cell selection.

  1. 1. Mechanisms of lymphocyte selection in physiology and autoimmune pathology

    Författare :Stina Forsgren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cell activation; la antigens; natural antibodies; non obese diabetic NOD ; T cell mediated autoimmunity; allophenic chimeras;

    Sammanfattning : .... LÄS MER

  3. 2. Aspects of T cell development contributing to autoimmunity

    Författare :Maria Carlsén; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FTOC; T cell development; Type 1 diabetes; p53; Insulin; NOD; Negative selection; TGF-β; Tolerance; Thymus; Conditional cre lox knock out; Autoimmunity;

    Sammanfattning : Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. LÄS MER

  4. 3. Glucocorticoid in T cell differentiation

    Författare :Yintong Xue; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Thymocytes differentiate into mature T cells with an immunological restriction for self major histocompatibility complex (MHC) antigens. Cells that do not recognize self MHC expressed on thymic epithelial cells (TEC) die by a rapid induction of apoptosis (default selection). LÄS MER

  5. 4. Engineered Alcohol Dehydrogenases for Stereoselective Chemical Transformations

    Författare :Thilak Reddy Enugala; Mikael Widersten; Manfred T. Reetz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; alcohol dehydrogenase-A; biocatalysts; protein engineering; enzyme kinetics; sec-alcohols; ketones; stereoselectivity; regioselectivity; substrate selectivity and promiscuity.; Biokemi; Biochemistry;

    Sammanfattning : Enzymes are biomolecules built from amino acids and catalyze the chemical transformations in a cell. Enzymes are by nature stereoselective, biodegradable, environmentally friendly, and can perform catalysis in aqueous solutions and at ambient temperatures. LÄS MER

  7. 5. Modelling T helper cell activation and development

    Författare :Andreas Jansson; Högskolan i Skövde; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; T cells; mathematical models; differentiation; computer simulation; mathematical models; cellular signal transduction; Bioinformatics; Bioinformatik; Natural sciences; Naturvetenskap; Technology; Teknik;

    Sammanfattning : T helper (Th) cell activation and development is one of the most critical events in regulating the adaptive immune response. Understanding its regulation could be of great therapeutical value as many severe diseases are associated with failure in controlling T cell activation and development. LÄS MER