Sökning: "Thymus"

Visar resultat 1 - 5 av 89 avhandlingar innehållade ordet Thymus.

  1. 1. Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus

    Författare :Katarzyna Sitnik; Slemhinnans immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thymus; mesenchymal cells; retinoic acid; thymic epithelial cells;

    Sammanfattning : T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where bone marrow-derived progenitors migrate in a co-ordinated fashion through anatomically distinct cortical and medullary regions that are composed of epithelial and mesenchymal stromal elements. LÄS MER

  2. 2. Inhibition of T cell responses to autoantigens and allergens by CD25+ regulatory T cells from thymus, cord and adult blood

    Författare :Kajsa Wing; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Tolerance; CD25 regulatory T cells; adult peripheral blood; cord blood; thymus; autoimmune disease; allergy;

    Sammanfattning : Autoimmune diseases and allergies are a growing problem in the western world today. Tolerance is primarily established by clonal deletion in the thymus. Despite this auto-reactive T cells are normally present in most individuals, which suggests that mechanisms of peripheral tolerance operate to silence potentially pathogenic T cells. LÄS MER

  3. 3. Generation of lymphocytes in the thymus : a study of morphologic, antigenic and functional development of lymphocytes in embryonic thymus organ cultures

    Författare :Roger Juhlin; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 4. Thymic studies. Investigations into the effects of childhood thymectomy, and characterization of thymic B cells and Hassall's corpuscles

    Författare :Christina Lundqvist; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thymus; thymectomy; TCR; B cells; APC; Hassall s corpuscles; AIRE;

    Sammanfattning : This thesis focuses on the human thymus, a primary lymphoid organ responsible for the maturation of T cells. Progenitors arrive from the bone marrow and start to randomly assemble their T cell receptor (TCR) followed by a thorough selection process in which the TCR is tested for functionality and autoreactivity. LÄS MER

  5. 5. Characteristics and functions of thymic exosomes in human and mouse

    Författare :Gabriel Skogberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exosome; thymus; tissue-restricted antigen; Aire; Down syndrome;

    Sammanfattning : Thymocytes develop in the thymus to become a functional pool of T-cells in the periphery. To achieve this, the thymocytes go through several steps of maturation and selection within the thymus. LÄS MER