Sökning: "Mikael Widersten"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden Mikael Widersten.
1. Protein–DNA Recognition : In Vitro Evolution and Characterization of DNA-Binding Proteins
Sammanfattning : DNA-recognizing proteins are involved in a multitude of important life-processes. Therefore, it is of great interest to understand the underlying mechanisms that set the rules for sequence specific protein–DNA interactions. Previous attempts aiming to resolve these interactions have been focused on naturally occurring systems. LÄS MER
2. Glutathione transferases : studies on the structure and function of recombinant enzymes
Sammanfattning : .... LÄS MER
3. Carboligation using the aldol reaction : A comparison of stereoselectivity and methods
Sammanfattning : The research summarized in this thesis focuses on synthesizing aldehyde and aldol compounds as substrates and products for the enzyme D-fructose-6-aldolase (FSA). Aldolases are important enzymes for the formation of carbon-carbon bonds in nature. LÄS MER
4. Computational modelling of enzyme selectivity
Sammanfattning : Enantioselective reactions are one of the ways to produce pure chiral compounds. Understanding the basis of this selectivity makes it possible to guide enzyme design towards more efficient catalysts. LÄS MER
5. Oxidation of 1,2-Diols Using Alcohol Dehydrogenases : From Kinetic Characterization to Directed Evolution
Sammanfattning : The use of enzymes as catalysts for chemical transformations has emerged as a “greener” alternative to traditional organic synthesis. An issue to solve though, is that enzymes are designed by nature to catalyze reactions in a living cell and therefore, in many cases, do not meet the requirements of a suitable biocatalyst. LÄS MER