Sökning: "Negative selection"

Visar resultat 1 - 5 av 223 avhandlingar innehållade orden Negative selection.

  1. 1. Robust inference of gene regulatory networks System properties, variable selection, subnetworks, and design of experiments

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Torbjörn E. M. Nordling; KTH.; [2013]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; network inference; reverse engineering; variable selection; model selection; feature selection; subset selection; system identification; system theory; network theory; subnetworks; design of experiments; perturbation experiments; gene regulatory networks; biological networks;

    Sammanfattning : In this thesis, inference of biological networks from in vivo data generated by perturbation experiments is considered, i.e. deduction of causal interactions that exist among the observed variables. Knowledge of such regulatory influences is essential in biology. LÄS MER

  2. 2. Tracing selection and adaptation along an environmental gradient in Populus tremula

    Detta är en avhandling från Umeå : Institutionen för Ekologi, miljö och geovetenskap, Umeå universitet

    Författare :David Hall; Umeå universitet.; [2009]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Local adaptation; Selection; genetic differentiation; QST; FST; Association study; frequency spectra; recurrent hitchhiking; selective sweep; Tree; Populus; natural selection; quantitative genetics; NATURAL SCIENCES Biology Terrestrial; freshwater and marine ecology Terrestrial ecology; NATURVETENSKAP Biologi Terrestrisk; limnisk och marin ekologi Terrestrisk ekologi; Population Biology; populationsbiologi; genetik; Genetics;

    Sammanfattning : The distribution of the expressed genotype is moved around in the population over time byevolution. Natural selection is one of the forces that act on the phenotype to change the patterns ofnucleotide variation underlying those distributions. LÄS MER

  3. 3. Biological and Pharmacological Factor that Influence the Selection of Antibiotic Resistance

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ingegerd Gustafsson; Uppsala universitet.; [2003]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Human microflora; antibiotic resistance; selection; mutation frequency; biological fitness; pharmacokinetics; pharmacodynamics; β-lactam antibiotics; suboptimal dosing regimen; Mikrobiologi; NATURAL SCIENCES Biology Organism biology Microbiology; NATURVETENSKAP Biologi Organismbiologi Mikrobiologi; Klinisk bakteriologi; Clinical Bacteriology;

    Sammanfattning : Antibiotic treatment causes an ecological disturbance on the human microflora. Four commensal bacteria: E. coli, enterococci, a-streptococci and coagulase-negative staphylococci, from patients with extensive, high antibiotic usage were investigated with regard to resistance pattern and mutation frequency. LÄS MER

  4. 4. Bioinformatic Analysis of Mutation and Selection in the Vertebrate Non-coding Genome

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mikael Brandström; Uppsala universitet.; [2007]
    Nyckelord :Biology; non-coding genome; selection; mutation; chicken; human; indel; microsatellite; sequence alignment; comparative genomics; bioinformatics; vertebrate; Biologi;

    Sammanfattning : The majority of the vertebrate genome sequence is not coding for proteins. In recent years, the evolution of this noncoding fraction of the genome has gained interest. These studies have been greatly facilitated by the availability of full genome sequences. LÄS MER

  5. 5. The Effects of Mutation and Selection on the Rate and Pattern of Molecular Evolution in Birds

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sofia Berlin; Uppsala universitet.; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; substitution rate; diversity; selection; male mutation bias; birds; Genetik; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik;

    Sammanfattning : By comparing sequence diversity and divergence on sex chromosomes one can study how the rate of evolution in affected by mutation and/or selection. The rate of mutation in male biased, meaning that relatively more mutations are created in the male germ line than in the female. LÄS MER