Sökning: "natural antibodies"

Visar resultat 1 - 5 av 352 avhandlingar innehållade orden natural antibodies.

  1. 1. Platforms and strategies harnessing signaling pathways of multifactorial diseases by multispecific antibodies

    Författare :Aman Mebrahtu; Johan Rockberg; Fredrik Y. Frejd; Janine Schuurman; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibodies; Bispecific antibodies; Multispecific affinity proteins; Protein engineering; Protein expression; Cancer; Immunotherapy; Autoimmunity; Systemic Lupus Erythematosus; Affibody molecules; AffiMab; Antikroppar; Bispecifika antikroppar; Multispecifika affinitets protein; Protein engineering; Protein uttryck; Cancer; Immunoterapai; Autoimmunitet; Systemic Lupus Erythematosus; Affibody molekyler; AffiMab; Biotechnology; Bioteknologi;

    Sammanfattning : Abstract [ENG]Proteins govern a multitude of biological functions vital to sustain life. The ability to withstand diseases development and harboring a defense against foreign pathogens is attributed to the wonders of the immune system and the proteins and cells its comprised of. LÄS MER

  3. 2. Calcium-dependent Affinity Domains for the Purification of Antibodies and Antibody Fragments

    Författare :Julia Scheffel; Sophia Hober; Alois Jungbauer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Antibodies; Antibody fragments; Biomanufacturing; Protein purification; Protein engineering; Protein A; ZCa; Calcium; Mild elution; Bioteknologi; Biotechnology;

    Sammanfattning : Antibodies are essential proteins in both our bodies and biotechnological research, and hold outstanding therapeutic value. The market for antibody-based therapeutics has grown exponentially during the last decades, owing to several advantages over small molecule drugs, such as fewer undesirable side effects associated with a higher target specificity. LÄS MER

  4. 3. Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications

    Författare :Thi Thuy Tran; Gunnar Thorsén; McLean John; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microfluidic CD; therapeutic antibodies; post-translational modifications; glycosylation profiling; multivariate statistical analysis; MALDI-MS; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. LÄS MER

  5. 4. Recombinant Antibodies – Tools for building proteomic platforms

    Författare :Anna Säll; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody development; recombinant scFv antibodies; phage display; affinity proteomics; mass spectrometry;

    Sammanfattning : This thesis, which is based on four original papers, covers different aspects of the evolvement and development of proteomic platforms and the construction of human synthetic antibody libraries for the isolation of antibody reagents has been very central. There is an accelerating need for technologies capable of providing proteomic analysis of high sensitivity with good accuracy and an overall broad coverage as well as for biomarker validation. LÄS MER

  7. 5. Astatine-211 and Iodine Conjugates: Radiohalogenation and Preclinical Pharmacokinetics for Targeted and Pretargeted Radioimmunotherapy

    Författare :Sture Lindegren; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; antibodies; dry-distillation; radiohalogenation; pretargeting; iodine; astatine-211;

    Sammanfattning : Endoradiotherapy using labelled tumour specific-monoclonal antibodies in the therapy of malignant disease is a therapeutic modality that is coming of age. While clearly defined tumours can be treated with surgery and/or chemotherapy, occult metastases requires adjuvant systemic treatment, e.g. LÄS MER