Sökning: "Institutionen för experimentell medicinsk vetenskap"

Visar resultat 26 - 30 av 101 avhandlingar innehållade orden Institutionen för experimentell medicinsk vetenskap.

  1. 26. Regulation of exocytosis by Ca2+ and cAMP - A study on pancreatic beta- and alpha-cells

    Författare :Xiaosong Ma; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Endocrinology; secreting systems; type-2 diabetes; SUR1; Ca2 -channel; glucagon; exocytosis; insulin; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Type-2 diabetes is characterized by impaired insulin secretion associated with excess glucagon release. Exocytosis of insulin- or glucagon-containing granules is initiated by Ca2+-influx through voltage-dependent Ca2+-channels and is modulated by the second messengers such as cAMP. LÄS MER

  3. 27. Neurogenesis in the adult brain from ballyhoo to sobriety

    Författare :Helena Frielingsdorf; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurofysiologi; Neurologi; neurophysiology; neuropsychology; Neurology; Nerve growth factor; acetylcholine; GABA; learning; hippocampus; Neurogenesis; dopamine; substantia nigra;

    Sammanfattning : New neurons are spontaneously generated in two regions of the adult brain, the hippocampus and the subventricular zone/olfactory bulb. The objective of this thesis was to study potential implications for adult neurogenesis in Alzheimer's (AD) and Parkinson's diseases (PD). LÄS MER

  4. 28. Aiway Mucins: experimental models for studies of secretions

    Författare :Naila Svitacheva; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cystic fibrosis; bovine trachea; radiolabelling; cell line; primary cell culture; organ culture; mucus; mucin; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Mucins are essential components of the mucosal barrier. The complexity of the airway mucosal barrier is reflected in the lack of specific treatments to block mucin hypersecretion associated with several respiratory diseases such as chronic bronchitis, asthma and cystic fibrosis. LÄS MER

  5. 29. The Role of Phosphodiesterase 3B in the Regulation of Insulin Secretion

    Författare :Linda Härndahl; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; beta-cell; diabetes; islet; PDE3B; cAMP;

    Sammanfattning : Pancreatic beta-cell dysfunction and insulin resistance are the two hallmarks of type 2 diabetes. An early sign of beta-cell dysfunction is impaired nutrient-induced insulin release. Several insulin secretagogues act by increasing the formation of intracellular cAMP. LÄS MER

  7. 30. Hormone-sensitive lipase: Molecular analyses of the human gene; structural and evolutionary aspects on expression, alternative splicing and cold adaptation

    Författare :Henrik Laurell; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymologi; Proteiner; Proteins; enzymology;

    Sammanfattning : Hormone-sensitive lipase (HSL) is a key enzyme in adipose tissue that hydrolyses stored fat (triacylglycerol). The activity of HSL is under strict hormonal and neural control. LÄS MER