Sökning: "SUR1"

Hittade 4 avhandlingar innehållade ordet SUR1.

  1. 1. Regulation of exocytosis by Ca2+ and cAMP - A study on pancreatic beta- and alpha-cells

    Författare :Xiaosong Ma; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Endocrinology; secreting systems; type-2 diabetes; SUR1; Ca2 -channel; glucagon; exocytosis; insulin; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Type-2 diabetes is characterized by impaired insulin secretion associated with excess glucagon release. Exocytosis of insulin- or glucagon-containing granules is initiated by Ca2+-influx through voltage-dependent Ca2+-channels and is modulated by the second messengers such as cAMP. LÄS MER

  3. 2. Metabolic signals and the ATP-sensitive potassium channel in the pancreatic beta-cell

    Författare :Robert Bränström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ATP-regulated K channel; pancreatic [beta]-cell oscillations; [alpha]-ketoisocaproate; long chain acyl-CoA esters; Kir6.2 SUR1 structure-function.;

    Sammanfattning : ATP-sensitive K+ (KATP) channels are widely distributed in a variety of tissues and cell types. KATP channels are comprised of two subunits, a pore forming subunit (Kir6.x) and a regulatory sulfonylurea receptor (SURx). Both subunits are required for fully functional channels. LÄS MER

  4. 3. Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282

    Författare :Vladimir Sharoyko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Insulin secretion; pancreatic islets; imidazolines; BL11282; arachidonic acid; phospholipase; cytochrome P-450; GLP-1; desensitization; Rhes;

    Sammanfattning : We developed a novel, pure glucose-dependent, insulinotropic imidazoline compound, BL11282, which directly affects the insulin exocytotic machinery and does not block the KATP channel activity. BL11282 does not induce insulin secretion at basal glucose concentrations, whereas it stimulates insulin secretion at an elevated glucose level. LÄS MER

  5. 4. Genetic and immunological risk factors of gestational diabetes mellitus

    Författare :Nael Shaat; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GDM; Association; genetics; gestational diabetes mellitus metabolic syndrome; MODY; type 1 diabetes; risk factors; type 2 diabetes; Endocrinology; diabetology; secreting systems; autoimmunity; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Gestational diabetes mellitus (GDM) is a heterogeneous disorder that is defined as carbohydrate intolerance with onset or first recognition during pregnancy. Impaired beta-cell function and insulin resistance are the hallmarks of GDM. LÄS MER