Sökning: "Gene therapy"

Visar resultat 1 - 5 av 624 avhandlingar innehållade orden Gene therapy.

  1. 1. Gene therapy of neuroblastoma

    Detta är en avhandling från Göteborg

    Författare :Yvonne Arvidsson; Göteborgs universitet.; Gothenburg University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; gene therapy; PNP; ASK1; MASH1; IL-12; GM-CSF; immunotherapy; apoptosis.;

    Sammanfattning : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. LÄS MER

  3. 2. Towards Gene Therapy of Osteopetrosis

    Detta är en avhandling från Department of Molecular Medicine and Gene Therapy, Lund University

    Författare :Maria Askmyr; Lund University.; Lunds universitet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; oc oc mice; osteoclast; hematopoietic stem cells; Hematologi; extracellulära vätskor;

    Sammanfattning : The goal in this thesis is development of gene therapy for malignant infantile osteopetrosis (IMO), a rare but severe genetic bone disease. The concept of osteopetrosis implies dysfunction or lack of osteoclasts, the bone resorbing cells in our body, resulting in failure of normal bone breakdown. LÄS MER

  4. 3. Gene Therapy for Neurological Disorders

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Jan Tönnesen; Lund University.; Lunds universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epileptiform activity; striatum; organotypic culture; electrophysiology; Wnt5a; synaptic connectivity.; cell transplantation; hippocampus; neural stem cells; epilepsy; functional integration; Parkinson’s disease; optogenetics; Gene therapy;

    Sammanfattning : Gene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. LÄS MER

  5. 4. TARP Promoter-Based Prostate Cancer Gene Therapy From Development to Application

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Wing-Shing Cheng; Uppsala universitet.; [2005]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Genetic engineering; TARP; PPT; TSTA; promoter; gene regulation; prostate specificity; hormone- independent; adenovirus; prostate cancer; gene therapy; conditionally replicating adenovirus; Genteknik; TECHNOLOGY Bioengineering Genetic engineering including functional genomics; TEKNIKVETENSKAP Bioteknik Genteknik inkl. funktionsgenomik;

    Sammanfattning : Prostate cancer is one leading cause of cancer-related death among men in Western countries. The standard therapies for localized prostate cancer include radical prostatectomy and radiation therapy. Such measures are relatively effective in the short term, but many patients ultimately relapse. LÄS MER

  7. 5. Astrocytes as Cellular Vehicles in Ex Vivo Gene Therapy Studies to the Rat Brain

    Detta är en avhandling från Grahns Tryckeri AB, Lund

    Författare :Cecilia Ericson; Lund University.; Lunds universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Lentivirus; Transplantation; CNS; Astrocytes;

    Sammanfattning : Neurodegenerative disorders are characterized by a progressive cell-death in the brain, and loss of different functions in the patient. Today, there are no cures for any of the various diseases. Parkinson's disease is a neurodegenerative disorder with a prevalence of 0. LÄS MER