Sökning: "Gene therapy"

Visar resultat 1 - 5 av 622 avhandlingar innehållade orden Gene therapy.

  1. 1. Gene therapy of neuroblastoma

    Detta är en avhandling från Göteborg

    Författare :Yvonne Arvidsson; Göteborgs universitet.; Gothenburg University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; gene therapy; PNP; ASK1; MASH1; IL-12; GM-CSF; immunotherapy; apoptosis.;

    Sammanfattning : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. LÄS MER

  2. 2. Gene Therapy for Neurological Disorders

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Jan Tönnesen; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epileptiform activity; striatum; organotypic culture; electrophysiology; Wnt5a; synaptic connectivity.; cell transplantation; hippocampus; neural stem cells; epilepsy; functional integration; Parkinson’s disease; optogenetics; Gene therapy;

    Sammanfattning : Gene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. LÄS MER

  3. 3. TARP Promoter-Based Prostate Cancer Gene Therapy From Development to Application

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Wing-Shing Cheng; Magnus Essand; Thomas H. Tötterman; Cecilia Lundberg; [2005]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Genetic engineering; TARP; PPT; TSTA; promoter; gene regulation; prostate specificity; hormone- independent; adenovirus; prostate cancer; gene therapy; conditionally replicating adenovirus; Genteknik; TECHNOLOGY Bioengineering Genetic engineering including functional genomics; TEKNIKVETENSKAP Bioteknik Genteknik inkl. funktionsgenomik;

    Sammanfattning : Prostate cancer is one leading cause of cancer-related death among men in Western countries. The standard therapies for localized prostate cancer include radical prostatectomy and radiation therapy. Such measures are relatively effective in the short term, but many patients ultimately relapse. LÄS MER

  4. 4. Gene therapy tools: oligonucleotides and peptides

    Detta är en avhandling från Stockholm : Department of Neurochemistry, Stockholm University

    Författare :Jonas Eriksson; Ülo Langel; Jens Kurreck; [2016]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gene therapy; oligonucleotide; peptide; RNA-cleaving deoxyribozyme; deoxyribozyme; DNAzyme; cell-penetrating peptide; CPP; enzyme; enzyme kinetics; kinetic assay; assay; telomerase; telomerase inhibitor; imetelstat; GRN163L; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. LÄS MER

  5. 5. Immunogene Therapy of Bladder Carcinoma A Preclinical Study

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Angelica Loskog; Rolf Kiessling; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Immunotherapy; Gene therapy; Immunogene therapy; CD40L; Bladder carcinoma; Onkologi; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : This thesis comprises studies on murine and human models of bladder carcinoma with the aim to develop novel immunogene therapies. On the basis of the results presented in this thesis, a clinical trial is underway.The potential of activating the immune system to combat cancer has long intrigued immunologists. LÄS MER