Sökning: "cell-penetrating peptide"

Visar resultat 1 - 5 av 66 avhandlingar innehållade orden cell-penetrating peptide.

  1. 1. Cell-penetrating peptides : an uptake mechanism & a new endosomolytic peptide

    Författare :Henrik Helmfors; Ülo Langel; Andreas Barth; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; cell-penetrating peptides; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Peptide-based drugs have slowly begun migrating from laboratories into pharmacies and now there are several on the market. However, currently only one gene based therapy that is relies on a viral delivery vector has been approved. LÄS MER

  2. 2. Cell-penetrating peptides : Uptake mechanism and the role of receptors

    Författare :Henrik Helmfors; Ülo Langel; Hanne Mørck Nielsen; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Genes are the major regulators of biological processes in every living thing. Problems with gene regulation can cause serious problems for the organism; for example, most cancers have some kind of genetic component. Regulation of biological processes using oligonucleotides can potentially be a therapy for any ailment, not just cancer. LÄS MER

  3. 3. Cell-penetrating peptides : Uptake, stability and biological activity

    Författare :Tina Holm; Ülo Langel; Roland Brock; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

    Sammanfattning : Cell-penetrating peptides (CPPs) have emerged as a group of remarkable delivery vectors for various hydrophilic macromolecules, otherwise excluded from cells due to the protective plasma membrane. Unbiased conclusions regarding e.g. LÄS MER

  4. 4. Cell-penetrating peptide targeting mitochondria : Design, synthesis, characterization, and biological effects

    Författare :Carmine Pasquale Cerrato; Ülo Langel; Lena Mäler; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; cell-penetrating peptide; mitochondrial targeting; ROS reduction; mitochondrial membrane potential; antioxidant activity; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : More than twenty years after the discovery of the first cell-penetrating peptide (CPP), a large number of both naturally occurring as well as engineered CPPs have been discovered. Generally, CPPs are short polycationic sequences of less than 30 amino acids that are able to translocate different cargoes into cells. LÄS MER

  5. 5. CELL PENETRATING PEPTIDES : CHEMICAL MODIFICATION AND FORMULATION DEVELOPMENT

    Författare :Kariem Ezzat; Ülo Langel; Astrid Gräslund; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; neurokemi med molekylär neurobiologi; Neurochemistry and Molecular Neurobiology;

    Sammanfattning : Cell penetrating peptides (CPPs) have been extensively studied and exploited as drug delivery vectors for a wide variety of therapeu-tic cargos. However, several issues remain to be addressed regarding the enhancement of their efficiency and stability. LÄS MER