Sökning: "multiple-unit release"
Hittade 5 avhandlingar innehållade orden multiple-unit release.
1. Modelling of Drug Release from Reservoir and Matrix Formulations - Multiple Unit Dosage Forms and Swelling and Dissolving Matrix Systems
Sammanfattning : In this work, mathematical models have been developed describing drug release from film-coated reservoir systems as well as drug release and polymer dissolution from swelling and dissolving polymer tablets. The model derivation of both systems is based on a mechanistic approach. The model describing drug release from reservoir systems, i.e. LÄS MER
2. Extended-release metoprolol : studies on the drug release and pharmacokinetics of a multiple-unit formulation
Sammanfattning : .... LÄS MER
3. Characterization of the Mechanisms of Drug Release from Polymer-Coated Formulations using Experiments and Modelling
Sammanfattning : The main objectives of the work presented in this thesis were to develop new experimental methods to improve the understanding of the release mechanism from a coated formulation and to develop new mechanistic models to describe the release process for pellets coated with a semi-permeable film. Another aim was to characterize the release mechanism from a formulation coated with films made of a blend of a water-insoluble polymer, ethyl cellulose (EC), and a water-soluble polymer, hydroxypropyl cellulose (HPC). LÄS MER
4. Preparation of Tablets from Reservoir Pellets with an Emphasis on the Compression Behaviour and Drug Release
Sammanfattning : The preparation of multiple unit tablets was investigated in this thesis with the intention of gaining a deeper understanding of some of the factors that influence the properties of such tablets.Initially, three different types of pellets (drug, soft and disintegrant pellets) were combined as a model to investigate the ability of the mixture to form disintegrating tablets. LÄS MER
5. Development and application of advanced electron microscopy techniques for materials in biological systems
Sammanfattning : Theoretically, electron microscopy and scanning probe microscopy offer information on a scale beyond the optical microscope. However, the quality of the micrograph and the obtained information is limited by the sample preparation. LÄS MER