Sökning: "oligonucleotide"
Visar resultat 1 - 5 av 151 avhandlingar innehållade ordet oligonucleotide.
1. Rational modifications of cell-penetrating peptides for drug delivery : Applications in tumor targeting and oligonucleotide delivery
Sammanfattning : High molecular weight biomolecules are becoming important in the development of new therapeutics. However, their size and nature creates a major limitation for their application – poor penetration through biological membranes. LÄS MER
2. Cell-penetrating peptides in protein mimicry and oligonucleotide delivery : Applications and mechanisms
Sammanfattning : The plasma membrane functions as a barrier, restricting entry of hydrophilic pharmaceutical agents. Cell-penetrating peptides (CPPs) are capable of transporting bioactive cargos into the cell and have consequently been extensively investigated for their mechanism of entry and capability to deliver various cargos spanning from peptides to plasmids. LÄS MER
3. Novel Methods for Synthesis of High Quality Oligonucleotides
Sammanfattning : The first part of the work describes a procedure of oligonucleotide purification using a reversed-phase cartridge. The developed method employs a very efficient yet mild oligonucleotide detritylation on the cartridge support allowing fast purification of oligonucleotides regardless of their 5´-modification. LÄS MER
4. Specificity of antisense oligonucleotide derivatives and cellular delivery by cell-penetrating peptides
Sammanfattning : Atypical gene expression has a major influence on the disease profile of several severe human disorders. Oligonucleotide (ON) based therapeutics has opened an avenue for compensating deviant protein expression by acting on biologically important nucleic acids, mainly RNAs. LÄS MER
5. Complexes of cell-penetrating peptides with oligonucleotides : Structure, binding and translocation in lipid membranes
Sammanfattning : The fundamental element of life known to man is the gene. The information contained in genes regulates all cellular functions, in health and disease. The ability to selectively alter genes or their transcript intermediates with designed molecular tools, as synthetic oligonucleotides, represents a paradigm shift in human medicine. LÄS MER