Sökning: "CAR T cells"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden CAR T cells.

1. 1. CAR T cells for Immunotherapy of Cancer

   Författare :Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

   Sammanfattning : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. LÄS MER

3. 2. Cancer Immunotherapy : Oncolytic viruses and CAR-T cells

   Författare :Jing Ma; Di Yu; Magnus Essand; Mia Phillipson; Mohanraj Ramachandran; Karl-Johan Malmberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer immunotherapy; Oncolytic viruses; chimeric antigen receptor CAR -T cells; Helicobacter pylori Neutrophil Activating Protein;

   Sammanfattning : Various forms of cancer immunotherapy have developed rapidly with improved survival and quality of life for cancer patients. Cancer immunotherapy aims to educate the patient’s immune system to eliminate cancer cells, including immune checkpoint inhibitors (ICIs), adoptive cell transfer (mostly T cells), oncolytic viruses (OVs) and cancer vaccines. LÄS MER

4. 3. CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside

   Författare :Hannah Karlsson; Angelica Loskog; Karl-Johan Malmberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chimeric antigen receptors; CAR T cells; T cell therapy; immunotherapy; CD19; Bcl-2 family inhibitors; B cell malignancies; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. LÄS MER

5. 4. The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy

   Författare :Victoria Hillerdal; Magnus Essand; Johanna Olweus; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; genetically engineered T cells; chimeric antigen receptor; T cell receptor; antigen-specific T cells; immunotherapy; Immunologi; Immunology; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. LÄS MER

7. 5. Cancer Immunotherapy : Evolving Oncolytic viruses and CAR T-cells

   Författare :Mohanraj Ramachandran; Magnus Essand; Di Yu; Justyna Leja-Jarblad; Richard Vile; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncolytic virus; Adenovirus; Semliki Forest virus; Cancer immunology; Chimeric antigen receptor T-cells; Immunologi; Immunology; Oncology; Onkologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Sammanfattning : In the last decade cancer immunotherapy has taken huge strides forward from bench to bedside and being approved as drugs. Cancer immunotherapy harnesses the power of patient’s own immune system to fight cancer. LÄS MER