Sökning: "ChIP-seq"
Visar resultat 26 - 30 av 40 avhandlingar innehållade ordet ChIP-seq.
26. Proteomics as a multifaceted tool in medicine and environmental assessment
Sammanfattning : Proteomics is evolving as a multi-faceted tool for addressing various biochemical and biomedical queries in the field of scientific research. This involves various stages, ranging from sample preparation to data analysis and biological interpretation. LÄS MER
27. Studies of the chromatin form of yeast Mediator and the function of its tail module
Sammanfattning : Mediator is a large, multifunctional complex that is conserved in eukaryotes. It was first discovered in Saccharomyces cerevisiaeas required for transcriptional activators to function in a reconstituted in vitro system. Mediator is also important for stimulation of basal, unregulated transcription, and transcriptional repression. LÄS MER
28. Deciphering the transcriptional regulation code in colorectal cancer genome
Sammanfattning : Colorectal cancer (CRC) is the third most common cancer type to threaten life for both men and women in the developed world. The molecular mechanism of CRC is very complicated and involves changes in different categories of biological processes, among which a large number of mutations affecting either coding sequence of transcription factors (TFs) or their binding sites in genome are included. LÄS MER
29. The interplay of transcription and chromatin regulation during embryonic development
Sammanfattning : A fascinating aspect of multicellular development is the production of diverse cell types from an identical DNA genome, which depends on the ability to express different complements of genes across space and time. This thesis tries to address how the genome, within the chromatin structure that envelops it, is regulated to direct this complex process. LÄS MER
30. Insights into the roles of the essential Pfh1 DNA helicase in the nuclear and mitochondrial genomes
Sammanfattning : Eukaryotic cells have two sets of genomes, the nuclear and mitochondrial, and both need to be accurately maintained. Also, the rate of transcription must be precisely regulated in these genomes. However, there are many natural barriers that dysregulate these processes. LÄS MER