Sökning: "ChIP-seq"

Visar resultat 16 - 20 av 40 avhandlingar innehållade ordet ChIP-seq.

  1. 16. Mechanisms of p53-mediated intrinsic and extrinsic tumor suppression

    Författare :Hai Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : p53 is a promising target for cancer therapy. However, the molecular basis of the p53 tumor suppression function remains incompletely understood. Thus, in this thesis, we focused on studies of the molecular mechanisms of p53-mediated tumor suppression. LÄS MER

  3. 17. Rule-Based Approaches for Large Biological Datasets Analysis : A Suite of Tools and Methods

    Författare :Marcin Kruczyk; Jan Komorowski; Joaquin Dopazo; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Rough sets; peak finding; gliomas; Alzheimer disease; STAT3; machine learning; feature selection; next generation sequencing;

    Sammanfattning : This thesis is about new and improved computational methods to analyze complex biological data produced by advanced biotechnologies. Such data is not only very large but it also is characterized by very high numbers of features. LÄS MER

  4. 18. Understanding Cancer Mutations by Genome Editing

    Författare :Muhammad Akhtar Ali; Tobias Associate Professor; Thierry Soussi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genome editing; rAAV; ZBED6; DIP2C; KRAS; BRAF; colorectal cancer; tumor driver genes; cancer pathways;

    Sammanfattning : Mutational analyses of cancer genomes have identified novel candidate cancer genes with hitherto unknown function in cancer. To enable phenotyping of mutations in such genes, we have developed a scalable technology for gene knock-in and knock-out in human somatic cells based on recombination-mediated construct generation and a computational tool to design gene targeting constructs. LÄS MER

  5. 19. Rule-based Models of Transcriptional Regulation and Complex Diseases : Applications and Development

    Författare :Susanne Bornelöv; Jan Komorowski; Claes Wadelius; Joanna Polanska; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone modification; Transcription factor; Transcriptional regulation; Next-generation sequencing; Feature selection; Machine learning; Rule-based classification; Asthma; Allergy; Bioinformatik; Bioinformatics;

    Sammanfattning : As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. LÄS MER

  7. 20. Gene regulation by different proteins of TGFβ superfamily

    Författare :Varun Maturi; Aristidis Moustakas; Anita Göndör; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; EMT; Snail1; ZEB1; TGFβ; BMP; Gene regulation;

    Sammanfattning : The present thesis discusses how gene regulation by transforming growth factor β (TGFβ) family cytokines is affected by post-translational modifications of different transcription factors. The thesis also focuses on gene regulation by transcription factors involved in TGFβ signaling. LÄS MER