Sökning: "Top1"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet Top1.

  1. 1. Insights into the roles of the essential Pfh1 DNA helicase in the nuclear and mitochondrial genomes

    Författare :Parham Pourbozorgi Langroudi; Nasim Sabouri; Anders Hofer; Per Sunnerhagen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G4; genome integrity; Pfh1; Top1; helicase; topoisomerase; replication; transcription;

    Sammanfattning : Eukaryotic cells have two sets of genomes, the nuclear and mitochondrial, and both need to be accurately maintained. Also, the rate of transcription must be precisely regulated in these genomes. However, there are many natural barriers that dysregulate these processes. LÄS MER

  3. 2. Investigating novel roles of topoisomerase regulatory interactions in transcription

    Författare :Vladislav Kuzin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drugs targeting DNA Topoisomerases (TOPs, TOP1 and TOP2) are mainstays of anti-cancer therapy. While they have proven effective, the toxicity of current TOP drugs caused by DNA damage-induced apoptosis of non-cancer cells, limits their use in the clinic. LÄS MER

  4. 3. DNA fragility in the context of neural stem cell fate : a multi-method integrative exploration of genome dynamics

    Författare :Roberto Ballarino; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Recent advances in mapping the complex genetic architecture underlying various debilitating brain disorders have enabled identification of several genetic risk variants. However, these risk variants only explain part of the heritability and vulnerability to these disorders in early development. LÄS MER

  5. 4. DNA topoisomerases and nucleosome dynamics in fission yeast

    Författare :Ulrika Norman Axelsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The organization of DNA and associated proteins into chromatin allows for compaction and protection of large eukaryotic genomes. However, it also poses a challenge to fundamental cellular processes such as DNA replication, recombination, repair and transcription. LÄS MER

  7. 5. The function of Smc5/6 in Drosophila development and at the heterochromatin-like locus HMR in budding yeast

    Författare :Martin Tran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The structural maintenance of chromosome 5/6 (Smc5/6) complex is one out of many factors in the cell that maintain genome stability. Smc5/6 has been implicated in processes such as DNA double-strand break (DSB) repair, replication progression, and chromosome segregation. LÄS MER