Sökning: "G4"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet G4.

1. 1. Biochemical analysis of Pfh1, the essential Pif1 family helicase in Schizosaccharomyces pombe

   Författare :Jani B. Mohammad; Nasim Sabouri; Erik Johansson; Per Elias; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; G4; Pfh1; Genome integrity; helicase; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : DNA stores the genetic information of all living organisms, and this information needs to be copied accurately and passed on to each daughter cell when a cell divides. However, the DNA replication machinery often meets obstacles in the genome that cause fork pausing and might result in DNA damage. LÄS MER

3. 2. Insights into the roles of the essential Pfh1 DNA helicase in the nuclear and mitochondrial genomes

   Författare :Parham Pourbozorgi Langroudi; Nasim Sabouri; Anders Hofer; Per Sunnerhagen; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G4; genome integrity; Pfh1; Top1; helicase; topoisomerase; replication; transcription;

   Sammanfattning : Eukaryotic cells have two sets of genomes, the nuclear and mitochondrial, and both need to be accurately maintained. Also, the rate of transcription must be precisely regulated in these genomes. However, there are many natural barriers that dysregulate these processes. LÄS MER

4. 3. Redefining the essential molecular aspects that drive interactions between small molecules and G-quadruplex DNA

   Författare :Måns Andréasson; Erik Chorell; Anna Linusson Jonsson; Jan Kihlberg; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; G-Quadruplexes; DNA; Oncogenes; G4 ligands; heterocycles; macrocycles; organic synthesis; molecular interactions; rational compound design; medicinal chemistry.; medicinal chemistry; läkemedelskemi; organisk kemi; Organic Chemistry;

   Sammanfattning : G-Quadruplex (G4) structures are secondary nucleic acid structures located in guanine-rich regions of DNA and RNA sequences, involved in gene regulation and cellular maintenance. Efforts to target G4s in a therapeutic setting are scarce, mainly due to vague details about the binding interactions between the ligands and the G4 structure combined with the lack of emphasis on drug-like properties early in the ligand development process. LÄS MER

5. 4. DNA G-quadruplex structures in the mammalian genome : dissecting genome-wide mechanisms of formation and turnover of DNA G-quadruplexes

   Författare :Jing Lyu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Since the beginning of 20th century, when the G-tetrad was first discovered, scientists have been seeking to understand the role of G4 quadruplex structures (G4s) in replication, DNA damage, telomere integrity and the regulation of gene expression. However, it is likely that the field has just scratched the tip of the iceberg when it comes to assessing and interpreting the function of individual G4s, forming in a specific locus, in the complex context of chromatin. LÄS MER

7. 5. Transcription kinetics in pluripotent cells : RNA turnover, transcription velocity, and epigenomic regulation

   Författare :Rui Shao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Transcriptional regulation is one of the primary steps in gene expression control. It is now appreciated that a large fraction of coding genome is transcribed in concert of other functional RNAs. LÄS MER