Sökning: "genome integrity"
Visar resultat 1 - 5 av 40 avhandlingar innehållade orden genome integrity.
- Detta är en avhandling från Stockholm : Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Sammanfattning : The RNA exosome acts on different RNA substrates and plays important roles in RNA metabolism. The fact that short non-coding RNAs are involved in the DNA damage response led us to investigate whether the exosome plays a role in DNA repair. LÄS MER
- Detta är en avhandling från Stockholm : Department of Molecular Biosciences, The Wenner-Gren Institute
Sammanfattning : The RNA exosome is a ribonucleolytic complex that acts on different RNA substrates and plays important roles in RNA metabolism. In recent years, the synthesis and the processing of RNA have been directly linked to the integrity of the genome. LÄS MER
- Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Cell and Molecular Biology
Sammanfattning : Correct segregation of sister chromatids is an important mechanism for keeping the genome intact. The cohesin complex holds the sister chromatids together from the time of their formation during replication, until separation at anaphase and is thereby mediating cohesion between the sister chromatids, essential for correct chromatid segregation. LÄS MER
- Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis
Sammanfattning : The human genome is a dynamic structure, recently recognized to present with significant large-scale structural variation. DNA-copy number changes represent one common type of such variation and is found both between individuals and within the somatic cells of the same individual, especially in disease states like cancer. LÄS MER
- Detta är en avhandling från Umeå : Umeå Universitet
Sammanfattning : DNA stores the genetic information of all living organisms, and this information needs to be copied accurately and passed on to each daughter cell when a cell divides. However, the DNA replication machinery often meets obstacles in the genome that cause fork pausing and might result in DNA damage. LÄS MER