Sökning: "Anders Hofer"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Anders Hofer.

  1. 1. Nucleotide Metabolism of the Human Pathogen Trypanosoma brucei

    Författare :Anders Hofer; Lars Thelander; Umeå universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  2. 2. Using de novo design proteins to explore tyrosine radicals and cation-π interactions

    Författare :Bruce W. Berry; Cecilia Tommos; Anders Hofer; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; tyrosine; radicals; cation-pi interactions; de novo designed proteins; biochemistry; biophysics; biokemi; Biochemistry;

    Sammanfattning : Redox cofactors and amino-acid free radicals play important roles in biology. Although many of the same cofactors and amino acids that form these radicals are found across a broad range of biological systems, identical cofactors can have different reduction potentials. The local environment plays a role in defining these redox potentials. LÄS MER

  3. 3. Class I Ribonucleotide Reductases : overall activity regulation, oligomerization, and drug targeting

    Författare :Venkateswara Rao Jonna; Anders Hofer; Arne Holmgren; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; GEMMA; Allosteric regulation; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Ribonucleotide reductase (RNR) is a key enzyme in the de novo biosynthesis and homeostatic maintenance of all four DNA building blocks by being able to make deoxyribonucleotides from the corresponding ribonucleotides. It is important for the cell to control the production of a balanced supply of the dNTPs to minimize misincorporations in DNA. LÄS MER

  4. 4. Activation and inhibition of diiron and iron-manganese ribonucleotide reductases

    Författare :Ana Popović-Bijelić; Astrid Gräslund; Anders Hofer; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; class Ic; C. trachomatis; cytotoxicity; KP772; lanthanum; manganese–iron cofactor; metal complex; oligopeptide inhibitor; ribonucleotide reductase; Triapine; tyrosyl radical; Biophysics; biofysik;

    Sammanfattning : Ribonucleotide reductase (RNR) catalyses the reduction of ribonucleotides to deoxyribonucleotides. In conventional class I RNRs the active site is located in the R1 subunit, and the R2 subunit contains a diiron cofactor and a stable tyrosyl radical essential for activity. LÄS MER

  5. 5. Insights into the roles of the essential Pfh1 DNA helicase in the nuclear and mitochondrial genomes

    Författare :Parham Pourbozorgi Langroudi; Nasim Sabouri; Anders Hofer; Per Sunnerhagen; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; G4; genome integrity; Pfh1; Top1; helicase; topoisomerase; replication; transcription;

    Sammanfattning : Eukaryotic cells have two sets of genomes, the nuclear and mitochondrial, and both need to be accurately maintained. Also, the rate of transcription must be precisely regulated in these genomes. However, there are many natural barriers that dysregulate these processes. LÄS MER