Sökning: "helicase"

Visar resultat 1 - 5 av 42 avhandlingar innehållade ordet helicase.

  1. 1. Biochemical analysis of Pfh1, the essential Pif1 family helicase in Schizosaccharomyces pombe

    Författare :Jani B. Mohammad; Nasim Sabouri; Erik Johansson; Per Elias; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; G4; Pfh1; Genome integrity; helicase; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : DNA stores the genetic information of all living organisms, and this information needs to be copied accurately and passed on to each daughter cell when a cell divides. However, the DNA replication machinery often meets obstacles in the genome that cause fork pausing and might result in DNA damage. LÄS MER

  3. 2. Insights into the roles of the essential Pfh1 DNA helicase in the nuclear and mitochondrial genomes

    Författare :Parham Pourbozorgi Langroudi; Nasim Sabouri; Anders Hofer; Per Sunnerhagen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G4; genome integrity; Pfh1; Top1; helicase; topoisomerase; replication; transcription;

    Sammanfattning : Eukaryotic cells have two sets of genomes, the nuclear and mitochondrial, and both need to be accurately maintained. Also, the rate of transcription must be precisely regulated in these genomes. However, there are many natural barriers that dysregulate these processes. LÄS MER

  4. 3. Activation of Herpes simplex virus type 1 origin of DNA replication

    Författare :Alireza Aslani; Göteborgs universitet; []
    Nyckelord :DNA replication; Herpes simplex virus; helicase; UL9; OBP; ICP8; ATP; oriS; hairpin;

    Sammanfattning : Herpes simplex virus type 1 has been used to study the molecular mechanism of DNA replication. Initiation of DNA replication takes place at specific regions called origins of replication. The HSV-1 genome contains three origins of replication, one copy of oriL and two copies of oriS. LÄS MER

  5. 4. Mechanisms for control of nucleoside triphosphate hydrolysis. Effects of DNA and RNA co-factors

    Författare :Bertil Macao; Göteborgs universitet; []
    Nyckelord :ATPase; GTPase; SRP; Ffh; FtsY; SRP RNA; OBP; UL9; oriS; oriS*; HSV-1; helicase.;

    Sammanfattning : In energetically unfavourable biological processes "protein machines" utilize chemical energy from the hydrolysis of high-energy phosphate bonds. Thus, the hydrolysis of a nucleoside triphosphate (NTP) to nucleoside diphosphate (NDP) with the release of free orthophosphate results in a liberation of energy. LÄS MER

  7. 5. Functional and structural characterization of the human mitochondrial helicase

    Författare :Jenny Korhonen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Mitochondria; mtDNA; replication; replisome; TWINKLE; mtSSB; POL g ; adPEO.;

    Sammanfattning : Mitochondria are the energy producing organelles of the eukaryotic cell. The human mitochondrial DNA (mtDNA) is a double stranded circular molecule of about 16 kb, usually present at 1000-10 000 copies per cell. The genome encodes 13 polypeptides involved in respiration, two ribosomal RNA s and a set of 22 transfer RNA s. LÄS MER