Sökning: "Pfh1"

Hittade 2 avhandlingar innehållade ordet Pfh1.

1. 1. Biochemical analysis of Pfh1, the essential Pif1 family helicase in Schizosaccharomyces pombe

   Författare :Jani B. Mohammad; Nasim Sabouri; Erik Johansson; Per Elias; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; G4; Pfh1; Genome integrity; helicase; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : DNA stores the genetic information of all living organisms, and this information needs to be copied accurately and passed on to each daughter cell when a cell divides. However, the DNA replication machinery often meets obstacles in the genome that cause fork pausing and might result in DNA damage. LÄS MER

3. 2. Insights into the roles of the essential Pfh1 DNA helicase in the nuclear and mitochondrial genomes

   Författare :Parham Pourbozorgi Langroudi; Nasim Sabouri; Anders Hofer; Per Sunnerhagen; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G4; genome integrity; Pfh1; Top1; helicase; topoisomerase; replication; transcription;

   Sammanfattning : Eukaryotic cells have two sets of genomes, the nuclear and mitochondrial, and both need to be accurately maintained. Also, the rate of transcription must be precisely regulated in these genomes. However, there are many natural barriers that dysregulate these processes. LÄS MER