Sökning: "chromatin-modifiers"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet chromatin-modifiers.
1. Mining DNA elements involved in targeting of chromatin modifiers
Sammanfattning : Background: In all higher organisms, the nuclear DNA is condensed into nucleosomes that consist of DNA wrapped around a core of highly conserved histone proteins. DNA bound to histones and other structural proteins form the chromatin. LÄS MER
2. The interplay of transcription and chromatin regulation during embryonic development
Sammanfattning : A fascinating aspect of multicellular development is the production of diverse cell types from an identical DNA genome, which depends on the ability to express different complements of genes across space and time. This thesis tries to address how the genome, within the chromatin structure that envelops it, is regulated to direct this complex process. LÄS MER
3. Epigenetic Regulation by Noncoding RNA
Sammanfattning : High throughput transcriptomic analyses have realized us with the fact that eukaryotic genome encodes thousands of noncoding RNAs (ncRNAs) with unknown function. In my thesis, I sought to address epigenetic regulation of transcription by ncRNA using the Kcnq1 imprinted cluster as a model system. LÄS MER
4. Transcriptional regulation of neural development and degeneration
Sammanfattning : The architecture and functional interactions of the cerebral cortex are fascinating in their complexity of billions of neurons and glial cells connected in intricate circuitries and spatial regions. During development, transcription factors and chromatin modifiers work together to coordinate gene expression programs that drive the formation of the cerebral cortex. LÄS MER
5. Molecular and epigenetic control of CNS tumour and progenitor cells
Sammanfattning : Despite advances in diagnosis and treatment, CNS tumours continue to result in high mortality and morbidity. Glioblastoma mutliforme (GBM), the most common primary brain tumour, is a recurrent tumour that despite advances in treatment, continues to demonstrate a median time of survival of 14.6 months. LÄS MER