Sökning: "Sox21"

Hittade 4 avhandlingar innehållade ordet Sox21.

  1. 1. Molecular and Cellular Complexity of Glioma : Highlights on the Double-Edged-Sword of Infiltration Versus Proliferation and the Involvement of T Cells

    Författare :Demet Çağlayan; Bengt Westermark; Maria Ferletta; Ana Martin-Villalba; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; Sox2; Sox21; Snail; Bone morphogenetic protein; Sleeping Beauty; Gliomatosis Cerebri; T lymphocytes; T regulatory lymphocytes; Oncology; Onkologi; Biology; Biologi;

    Sammanfattning : Glioblastoma multiforme (GBM), the most common and malignant brain tumor, is characterized by high molecular and cellular heterogeneity within and among tumors. Parameters such as invasive growth, infiltration of immune cells and endothelial proliferation contribute in a systemic manner to maintain the malignancy. LÄS MER

  3. 2. Sox proteins and neurogenesis

    Författare :Magnus Sandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The primordium of the central nervous system is specified in a process called neural induction at which point the ectoderm is subdivided into the epidermal ectoderm and the neural plate. With time the neural plate will thicken, fold and form the neural tube. LÄS MER

  4. 3. Regulation of neurogenesis in the vertebrate CNS

    Författare :Magdalena Källström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During development, neurons are generated from self-renewing progenitor cells in the ventricular zone of the neural tube. Proneural bHLH proteins are involved in the regulation of neurogenesis and can direct the exit of neural progenitors from the cell cycle and promote the expression of downstream differentiation markers. LÄS MER

  5. 4. SOX in development and disease

    Författare :Idha Kurtsdotter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : As stem cells are needed not only to build our bodies during development, but also to maintain tissue function during adulthood, it is of great importance to the organism to maintain their integrity. However, stem cells also pose a threat, as oncogenic mutations can transform them or their progeny to malignant cells giving rise to cancer. LÄS MER