Sökning: "ChIP-seq"
Visar resultat 6 - 10 av 40 avhandlingar innehållade ordet ChIP-seq.
6. DNA Sequence Variants in Human Autoimmune Diseases
Sammanfattning : Human autoimmune diseases are hallmarked by inappropriate loss-of-tolerance and self-attacking response of the immune system. Studies included in this thesis are focusing on the implication and functional impact of genetic factors in three autoimmune diseases rheumatoid arthritis (RA), asthma, and systemic lupus erythematosus (SLE). LÄS MER
7. Genome-wide epigenetic profiling of B cell leukemia and lymphoma
Sammanfattning : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. LÄS MER
8. A Bioinformatics Study of Human Transcriptional Regulation
Sammanfattning : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. LÄS MER
9. Bioinformatic approaches to gene expression in leukemia. Networks and deconvolution
Sammanfattning : The aim of this thesis is develop methods to extract information from high-dimensionality data and to apply them in looking at gene-gene and gene-protein interactions in Acute Myeloid Leukemia (AML). The in silico methods developed can be used with data from other systems. LÄS MER
10. Molecular mechanisms of Yersinia pseudotuberculosis for adaptation and establishment of infection in host tissue
Sammanfattning : Bacterial pathogens can evade the host’s immune defence to adapt and establish an infection within the host. Some even slip into a quiescent state to establish themselves without acutely harming the host. Phylogenetically unrelated bacteria can share similar strategies for the establishment of infection and for persistence. LÄS MER