Sökning: "medicinsk biokemi"

Visar resultat 1 - 5 av 717 avhandlingar innehållade orden medicinsk biokemi.

  1. 1. DNA precursor biosynthesis-allosteric regulation and medical applications

    Detta är en avhandling från Umeå : Medicinsk kemi och biofysik

    Författare :Reza Rofougaran; Umeå universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; DNA biosynthesis; ribonucleotide reductase; allosteric regulation; Trypanosoma brucei; adenosine kinase; nucleoside analogs; mitochondrial DNA; TWINKLE; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Ribonucleotide reductase (RNR) is a key enzyme for de novo dNTP biosynthesis. We have studied nucleotide-dependent oligomerization of the allosterically regulated mammalian RNR using a mass spectrometry–related technique called Gas-phase Electrophoretic Mobility Macromolecule Analysis (GEMMA). LÄS MER

  2. 2. Studies on the transmembrane signaling of β1 integrins

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Annika Armulik; Uppsala universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin β1; signaling; transmembrane domain; CAS; focal adhesion kinase; Biokemi; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Integrins are heterodimeric cell surface receptors, composed of an α and a β subunit, mainly binding for extracellular matrix proteins. lntegrin subunit β1 can combine with at least 12 a subunits and thus form the biggest subfamily within the integrin family. LÄS MER

  3. 3. Functional studies in yeast of cyclin C and the RNA polymerase II Mediator complex

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Darius Balciunas; Uppsala universitet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Cyclin C; RNA polymerase II; Mediator; glucose repression; RAS cAMP pathway; Saccharomyces cerevisiae; Biokemi; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Cyclin C belongs to a group of cyclins that are not cell cycle-regulated. It was first cloned from Drosophila and rat, but its role was not understood until the yeast cyclin C homologue Srb 11 was identified in several genetic screens for transcriptional repressors and subsequently was shown to be associated with the RNA polymerase II Mediator complex. LÄS MER

  4. 4. The expression and regulation of hyaluronan synthases and their role in glycosaminoglycan synthesis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jonas Brinck; Uppsala universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; hyaluronan; glycosaminoglycans; CD44; growth factors; UDP-glucose dehydrogenase; Biokemi; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : The glycosaminoglycan hyaluronan is an essential component of the extracellular matrix in all higher organisms, affecting cellular processes such as migration, proliferation and differentiation. Hyaluronan is synthesized by a plasma membrane bound hyaluronan synthase (HAS) which exists in three genetic isoforms. LÄS MER

  5. 5. The megalin receptor

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Göran Hjälm; Uppsala universitet.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; calcium; parathyroid; gp330; megalin; LRP-2; LDL-receptor super family; endogenous retroviruse; Biokemi; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Ionized calcium is a major player in the living organism. Its importance in both intra- and extracellular mechanisms have been studied in a broad number of publications. LÄS MER