Sökning: "Cell Nucleus metabolism"
Visar resultat 1 - 5 av 38 avhandlingar innehållade orden Cell Nucleus metabolism.
1. Micro-environmental control of tumor differentiation and invasiveness
Sammanfattning : The transforming growth factor β (TGFβ) family participates in embryonic development and adult tissue homeostasis. In early stages of tumorigenesis, TGFβ promotes cell cycle arrest and apoptosis; however, in advanced malignancies, TGFβ promotes tumor cell migration and metastasis via the induction of epithelial-tomesenchymal transition (EMT). LÄS MER
2. Interorganellar connectivity : From protein to lipid homeostasis
Sammanfattning : Interorganellar connectivity is fundamental for the maintenance of organellar and cellular functionality and viability. This is achieved and maintained by a complex network of signaling cascades, vesicle trafficking between organelles as well as by establishment of direct physical contact at membrane contact sites (MCS). LÄS MER
3. The cell biology and catalytic properties of the nutrient-induced signaling endoprotease Ssy5
Sammanfattning : Cells continuously sense and respond to changes in the presence, quality and quantity of external and internal nutrients. Specific signaling proteases have been identified based on their roles in processing or destruction of distinct sets of downstream effector proteins in response to environmental cues. LÄS MER
4. A molecular chaperone that governs membrane contact sites and lipid metabolism
Sammanfattning : Transmembrane proteins represent almost one third of the total cellular proteome, and the majority of them requires translocation into the endoplasmic reticulum (ER) to be folded, sorted and transported to their final subcellular destination. High translational rates during exponential cell growth result in a massive influx of immature proteins into the ER, requiring rapid and accurate folding. LÄS MER
5. Studies of penta-decameric binding proteins: AP-4 and CBF-A
Sammanfattning : Each immunoglobulin (Ig) V gene segment contains an upstream promoter region. The octamer element and the TATA box are the only elements that are conserved in all Ig promoters. The presence of the octamer element is necessary, but not sufficient to support high levels of transcription. LÄS MER