Sökning: "proteostasis"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet proteostasis.

  1. 1. Molecular And Cellular Networks in Critical Illness Associated Muscle Weakness : Skeletal Muscle Proteostasis in the Intensive Care Unit

    Författare :Varuna Chaminda Banduseela; Lars Larsson; Gustavo Nader; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chaperones; autophagy; intensive care unit; heat shock proteins; protein synthesis; proteostasis; ER stress; gene expression; sepsis; neuromuscular blockers; corticosteroids; immobilisation; mechanical ventilation; Molekylär cellbiologi; Molecular Cellbiology; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Critical illness associated muscle weakness and muscle dysfunction in intensive care unit (ICU) patients lead to severe morbidity and mortality as well as significant adverse effect on quality of life. Immobilization, mechanical ventilation, neuromuscular blocking agents, corticosteroids, and sepsis have been implicated as important risk factors, but the underlying molecular and cellular mechanisms remain unclear. LÄS MER

  3. 2. Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae

    Författare :Veronica Andersson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; aging; aggregates; proteostasis; proteasome; disaggregation; peroxiredoxins; asymmetric inheritance; S. cerevisiae;

    Sammanfattning : Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of any part of this proteostasis network may have severe consequences for cellular fitness and longevity. LÄS MER

  4. 3. Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin

    Författare :Sarah Hanzén; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging; Caloric restriction; Oxidative stress; Peroxiredoxins; Proteostasis; Protein aggregates; Ubiquitin-proteasome system;

    Sammanfattning : Aging is characterized by a progressive decline in physiological functions that limits biological processes, increases the risk of disease, and ultimately leads to death. At the cellular level, aging is associated with accumulation of damaged components, including proteins, indicating that protein homeostasis (or proteostasis) fails to maintain the integrity and functionality of the proteome as cells age. LÄS MER

  5. 4. Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins

    Författare :Rebecca Josefson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aging; proteostasis; protein quality control; asymmetric inheritance; vesicle trafficking;

    Sammanfattning : Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging factors, e.g. damaged and aggregated proteins. LÄS MER

  7. 5. Regulation of cellular Hsp70 : Proteostasis and aggregate management

    Författare :Jayasankar Mohanakrishnan Kaimal; Claes Andréasson; Pierre Goloubinoff; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Proteins have to be folded to their native structures to be functionally expressed. Misfolded proteins are proteotoxic and negatively impact on cellular fitness. To maintain the proteome functional proteins are under the constant surveillance of dedicated molecular chaperones that perform protein quality control (PQC). LÄS MER