Sökning: "Alexander Pietras"

Hittade 2 avhandlingar innehållade orden Alexander Pietras.

1. 1. Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization

   Författare :Alexander Pietras; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2alpha; cancer; notch; angiogenesis; tumor-initiating cells; hypoxia; neuroblastoma; differentiation;

   Sammanfattning : Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. LÄS MER

3. 2. Micro-environmental control of tumor differentiation and invasiveness

   Författare :Caroline Gélabert; Aristidis Moustakas; Alexander Pietras; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; cell signaling; TGFβ; non-coding RNAs; metabolism;

   Sammanfattning : The transforming growth factor β (TGFβ) family participates in embryonic development and adult tissue homeostasis. In early stages of tumorigenesis, TGFβ promotes cell cycle arrest and apoptosis; however, in advanced malignancies, TGFβ promotes tumor cell migration and metastasis via the induction of epithelial-tomesenchymal transition (EMT). LÄS MER