Sökning: "B Cox"

Visar resultat 1 - 5 av 47 avhandlingar innehållade orden B Cox.

  1. 1. Developmental disturbances of the embryo in diabetic pregnancy

    Författare :Parri Wentzel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; diabetes; pregnancy; embryo; malformation; glucose; ROS; SOD; NAC; prosta- glandin; COX; COX inhibitor; gene expression; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Maternal diabetes during pregnancy constitutes an increased risk for congenital malformation in the offspring. Previous studies have suggested that diabetic embryopathy is associated with an excess of reactive oxygen species (ROS) as well as with a disturbance of prostaglandin (PG) metabolism. LÄS MER

  3. 2. Involvement of Eicosanoid Signaling in Intestinal Epithelial Cell Survival

    Författare :John Öhd; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; Tcf Lef; Bcl-2 family; b-catenin; 5-LO; apoptosis; cell survival; colorectal cancer; COX-2; LTD4; CysLT1 R; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Sammanfattning : Eicosanoids are known to be involved in many different aspects of eukaryotic physiology and pathology. Notably, over the past 10 years much attention has been given to cyclooxygenase-2 (COX-2) due to its involvement in colorectal cancer. Less is known about the other major branch of arachidonic acid metabolism, namely the lipoxygenases (LO). LÄS MER

  4. 3. Involvement of eicosanoid signalling in epithelial cell migration

    Författare :Oliver Broom; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; histokemi; cytokemi; Medicin människa och djur ; Histology; Medicine human and vertebrates ; Biomedicinska vetenskaper; Biomedical sciences; Integrin; Eicosanoid; COX-2; Cell migration; cytochemistry; histochemistry; Histologi; tissue culture; vävnadskultur;

    Sammanfattning : The development of inflammatory bowel diseases (IBD) and colon cancer (CC) has been shown to involve the up-regulation of inflammatory mediators and the machinery producing them such as the eicosanoids. Changes in the expression of extracellular matrix proteins and their related integrin receptors have also been shown to be important in the advancement IBD and CC. LÄS MER

  5. 4. Influence of leukotriene D4 and cyclooxygenase-2 on cell survival

    Författare :Katarina Wikström; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pathological anatomy; Patologi allmän ; General pathology; colorectal cancer; inflammation; apoptosis; LTD4; COX-2; patologisk anatomi;

    Sammanfattning : The pro-inflammatory effect of leukotrienes is an important element in the pathogenesis of multiple disorders, including asthma and inflammatory bowel diseases (IBD). A serious concern for IBD patients is the increased risk of developing colorectal cancer and since there seems to be a general connection between inflammation and cancer we hypothesised that LTD4 induced signalling events could be involved in increasing the tumourgenic potential of cells. LÄS MER

  7. 5. The immune microenvironment of colorectal cancer - Relationship with survival, sidedness, and pre-diagnostic anthropometry

    Författare :Jonna Berntsson; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal Cancer; T cells; B cells; PD-1; PD-L1; immune system; prognosis; anthropometry; obesity;

    Sammanfattning : Colorectal cancer (CRC) is the third most common cancer worldwide. Increasing evidence suggests that CRC should be considered a heterogeneous disease, with multiple differences between proximal and distal tumours. LÄS MER