Sökning: "Tcf Lef"
Hittade 5 avhandlingar innehållade orden Tcf Lef.
Sammanfattning : Eicosanoids are known to be involved in many different aspects of eukaryotic physiology and pathology. Notably, over the past 10 years much attention has been given to cyclooxygenase-2 (COX-2) due to its involvement in colorectal cancer. Less is known about the other major branch of arachidonic acid metabolism, namely the lipoxygenases (LO). LÄS MER
Sammanfattning : The pro-inflammatory mediator LTD4 is an important component in the pathogenesis of inflammatory conditions as inflammatory bowel diseases. Patients suffering from inflammatory bowel diseases face an increased risk of intestinal cancer development. LÄS MER
Sammanfattning : Human development requires the generation of trillions of cells with myriad functions from a single cell. This requires that restriction of stem cell fate competence and proliferation are precisely temporally and spatially patterned as the embryo grows. LÄS MER
Sammanfattning : Abstract Colorectal cancer is the third most common cancer worldwide. Deregulation of Wnt/β-catenin signalling pathway is an early hallmark of colon cancer. Were nuclear accumulation of β-catenin is a marker of activated canonical Wnt/β-catenin signaling. One of the risk factors for development of colon cancer is inflammatory bowel disease. LÄS MER
Sammanfattning : Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable. The insulin-like growth factor 1 receptor, IGF-1R, has been demonstrated to play a critical part in tumorigenesis; downregulation of the IGF-1R in tumor xenografts results in complete tumor regression. LÄS MER