Sökning: "COX-2"

Visar resultat 1 - 5 av 116 avhandlingar innehållade ordet COX-2.

  1. 1. Immunotherapy and COX-2 inhibition against malignant brain tumors

    Författare :Sofia Eberstål; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malignant brain tumors; immunotherapy; IFN-γ; GM-CSF; COX-2 inhibition;

    Sammanfattning : Glioblastoma multiforme (GBM) is the most common primary brain tumor in the central nervous system and the prognosis is very poor despite conventional therapies including surgery, chemo- and radiotherapy. Peripheral vaccination with irradiated tumor cells represent a novel therapy that targets both dividing and non-dividing tumor cells and minimizes the risk of therapy resistance by presenting multiple tumor antigens. LÄS MER

  3. 2. Cox-2 inhibitors of natural origin : Dereplication, isolation, and structure elucidation

    Författare :Wimal Pathmasiri; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  4. 3. Involvement of eicosanoid signalling in epithelial cell migration

    Författare :Oliver Broom; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; histokemi; cytokemi; Medicin människa och djur ; Histology; Medicine human and vertebrates ; Biomedicinska vetenskaper; Biomedical sciences; Integrin; Eicosanoid; COX-2; Cell migration; cytochemistry; histochemistry; Histologi; tissue culture; vävnadskultur;

    Sammanfattning : The development of inflammatory bowel diseases (IBD) and colon cancer (CC) has been shown to involve the up-regulation of inflammatory mediators and the machinery producing them such as the eicosanoids. Changes in the expression of extracellular matrix proteins and their related integrin receptors have also been shown to be important in the advancement IBD and CC. LÄS MER

  5. 4. Carbonate Ions and Gastric Cancer

    Författare :Roy Ehrnström; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; ODC; COX-2; inflammation; Wistar rats; duodenogastric reflux; Medicin människa och djur ; proliferation; gastrojejunostomy; carbonate ions; Experimental gastric cancer;

    Sammanfattning : Nearly one million new cases of gastric cancer are diagnosed annually throughout the world. Even though the incidence has fallen dramatically in recent decades, this disease is still the second leading cause of cancer death in a global perspective. LÄS MER

  7. 5. Influence of leukotriene D4 and cyclooxygenase-2 on cell survival

    Författare :Katarina Wikström; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pathological anatomy; Patologi allmän ; General pathology; colorectal cancer; inflammation; apoptosis; LTD4; COX-2; patologisk anatomi;

    Sammanfattning : The pro-inflammatory effect of leukotrienes is an important element in the pathogenesis of multiple disorders, including asthma and inflammatory bowel diseases (IBD). A serious concern for IBD patients is the increased risk of developing colorectal cancer and since there seems to be a general connection between inflammation and cancer we hypothesised that LTD4 induced signalling events could be involved in increasing the tumourgenic potential of cells. LÄS MER