Sökning: "stomach tumor"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden stomach tumor.

  1. 1. Multimodal treatment of gastric cancer : assessment of tumor regression and the role of minimally invasive surgery

    Författare :Andrianos Tsekrekos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The generally poor prognosis of advanced gastric cancer (AGC) has led to the development of multimodal therapeutic protocols in which surgery is combined with systemic treatment, perioperative chemotherapy being the preferred approach in Europe. In this context, there still are several issues that need to be addressed. LÄS MER

  3. 2. Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model

    Författare :Patrik Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dioxin Ah receptor; TCDD; dioxin; stomach tumor; osteopontin; peritoneal B1 B cells; transcription factor; gene expression;

    Sammanfattning : The dioxin/ Aryl hydrocarbon receptor is a ligand-activated transcription factor that mediates most (if not all) of the toxic effects of the group of highly potent environmental pollutants collectively called dioxins and PCBs, including the highly toxic compound 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD). The toxic effects include immune suppression, endocrine disruption, impaired reproduction and carcinogenesis. LÄS MER

  4. 3. Studies on DNA adducts and carcinogenesis with 2-nitrofluorene as a model substance

    Författare :Xian-Shu Cui; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :2-nitrofluorene; carcinogens; DNA adducts; preneoplastic lesion; tumor;

    Sammanfattning : A number of carcinogens or their electrophilic intermediates are able to bind covalently to DNA, forming DNA adducts. DNA adducts may cause gene mutations if they are misrepaired or remain unrepaired before DNA replication occurs. DNA adduct formation is believed to be the initial step of chemical carcinogenesis. LÄS MER

  5. 4. Aspects of the etiology of gastric adenocarcinoma

    Författare :Krister Sjödahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Stomach; gastric; cancer; etiology; epidemiology; incidence; tobacco; smoking; alcohol; dust; occupational; physical activity; BMI; body mass; overweight; salt;

    Sammanfattning : Gastric adenocarcinoma is the fourth most common malignancy and the second leading cause of cancer death in the world. Tremendous effort has been made to look into the causation of gastric cancer. Etiological research plays a key role in identifying possible preventive and interventional measures. LÄS MER

  7. 5. Tumors associated with Hereditary Nonpolyposis Colorectal Cancer: Defective Mismatch Repair and Familial Risk of Cancer

    Författare :Kajsa Ericson Lindquist; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; cancerology; Cytologi; onkologi; cancer; Multiple Tumors; Hereditary Nonpolyposis Colorectal Cancer; Cytology; Cohort study; Population based; Familial Risk of Cancer; Immunohistochemistry; MSH2; MSH6; MLH1; Microsatellite Instability; Soft Tissue Sarcomas; Cancer of the Upper Urinary Tract; Cancer of the Small Intestine; Colorectal Cancer;

    Sammanfattning : Inactivation of the DNA mismatch repair (MMR) system is a tumorigenic mechanism involved in 15-20% of tumor types such as colorectal and endometrial cancer and is specifically associated with the Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome. These MMR defective tumors are characterized by microsatellite instability (MSI), a phenomenon that reflects alterations in length of repeated sequences, and 90% of MSI tumors show loss of immunohistochemical expression for the MMR protein affected. LÄS MER