Sökning: "Immunohistochemistry"

Visar resultat 1 - 5 av 616 avhandlingar innehållade ordet Immunohistochemistry.

  1. 1. Validation of antibodies for protein profiling A study using immunohistochemistry on tissue microarrays

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Linda Paavilainen; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody validation; monospecific antibodies; protein profiling; immunohistochemistry; tissue microarrays; western blot; fixatives; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi; Pathology; patologi;

    Sammanfattning : The field of proteomics has rapidly expanded due to the completion of the human genome sequence. This thesis validates affinity-purified monospecific antibodies of polyclonal origin, for protein profiling in a broad spectrum of normal tissues and cells. LÄS MER

  2. 2. Biomarker Discovery in Cutaneous Malignant Melanoma A Study Based on Tissue Microarrays and Immunohistochemistry

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Margrét Agnarsdóttir; Uppsala universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody-based proteomics; automated analysis; biomarker; immunohistochemistry; malignant melanoma; survival; tissue microarray; MEDICINE Morphology; cell biology; pathology Morphology Tumour biology; MEDICIN Morfologi; cellbiologi; patologi Morfologi Tumörbiologi; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi; MEDICINE Morphology; cell biology; pathology Pathology Molecular medicine; MEDICIN Morfologi; cellbiologi; patologi Patologi Molekylär medicin; Medical Science; Medicinsk vetenskap; Pathology; Patologi;

    Sammanfattning : The incidence of cutaneous malignant melanoma has increased dramatically in Caucasians the last few decades, an increase that is partly explained by altered sun exposure habits. For the individual patient, with a localized disease, the tumor thickness of the excised lesion is the most important prognostic factor. LÄS MER

  3. 3. Automated Tissue Image Analysis Using Pattern Recognition

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jimmy Azar; Uppsala universitet.; Uppsala universitet.; [2014]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; tissue image analysis; pattern recognition; digital histopathology; immunohistochemistry; paired antibodies; histological stain evaluation; Computerized Image Processing; Datoriserad bildbehandling;

    Sammanfattning : Automated tissue image analysis aims to develop algorithms for a variety of histological applications. This has important implications in the diagnostic grading of cancer such as in breast and prostate tissue, as well as in the quantification of prognostic and predictive biomarkers that may help assess the risk of recurrence and the responsiveness of tumors to endocrine therapy. LÄS MER

  4. 4. A methodological platform to study molecular biocompatibility of biomaterials. Experimental and clinical studies

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Maria Lennerås; Göteborgs universitet.; Gothenburg University.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osseointegration; titanium; inflammation; cell recruitment; cell adhesion; bone regeneration; bone remodelling; gene expression; immunohistochemistry; histomorphometry; removal torque; ultrastructure; FACS; protein profiling; transfemoral amputation; abutment; percutaneous; bacteria; clinical signs;

    Sammanfattning : The aim of this project was to develop a methodological platform in order to advance our scientific understanding of the mechanisms of osseointegration. Screw-shaped, titanium implants, with different surface properties, were inserted in the rat tibia, or incubated in mono- or co-culture of human monocytes and MSCs. LÄS MER

  5. 5. Affibody ligands in immunotechnology applications

    Detta är en avhandling från Stockholm : Bioteknologi

    Författare :Jenny Rönnmark; KTH.; [2002]
    Nyckelord :phage display; combinatorial; affinity; IgA ligand; immunohistochemistry; affibody-fusions;

    Sammanfattning : This thesis describes the development and use ofnon-immunoglobulin affinity proteins denoted affibodies asalternatives to antibodies in different immunotechnologyapplications. A 58 aa IgG Fc binding three-helix bundle domainZ, derived from staphylococcal protein A has been used asframework for library constructions, in which the face of themolecule involved in the native binding activity has beenengineered by combinatorial protein engineering. LÄS MER