Sökning: "Familial Risk of Cancer"

Visar resultat 1 - 5 av 69 avhandlingar innehållade orden Familial Risk of Cancer.

  1. 1. Prostate cancer epidemiological studies of risk factors

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Camilla Thellenberg Karlsson; Beatrice Malmer; Henrik Grönberg; Anders Bergh; Peter Iversen; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; epidemiology; SNP; BRCA2; male breast cancer; inflammation; BPH; P53; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi;

    Sammanfattning : In spite of the fact that prostate cancer is the most common male cancer in both Sweden and many other countries in the developed world, little is known of risk factors and predisposing conditions. The only well recognized risk factors are age, race and familial aggregation. LÄS MER

  2. 2. Tumors associated with Hereditary Nonpolyposis Colorectal Cancer: Defective Mismatch Repair and Familial Risk of Cancer

    Detta är en avhandling från Department of Oncology, Clinical Sciences, Lund University

    Författare :Kajsa Ericson Lindquist; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; cancerology; Cytologi; onkologi; cancer; Multiple Tumors; Hereditary Nonpolyposis Colorectal Cancer; Cytology; Cohort study; Population based; Familial Risk of Cancer; Immunohistochemistry; MSH2; MSH6; MLH1; Microsatellite Instability; Soft Tissue Sarcomas; Cancer of the Upper Urinary Tract; Cancer of the Small Intestine; Colorectal Cancer;

    Sammanfattning : Inactivation of the DNA mismatch repair (MMR) system is a tumorigenic mechanism involved in 15-20% of tumor types such as colorectal and endometrial cancer and is specifically associated with the Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome. These MMR defective tumors are characterized by microsatellite instability (MSI), a phenomenon that reflects alterations in length of repeated sequences, and 90% of MSI tumors show loss of immunohistochemical expression for the MMR protein affected. LÄS MER

  3. 3. Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations

    Detta är en avhandling från Department of Oncology, Clinical Sciences, Lund University

    Författare :Susanne Magnusson; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood cancer; hereditary factors; breast cancer; survival; hereditary breast and ovarian cancer; hereditary non-polyposis colorectal cancer; familial malignant melanoma; BRCA1; BRCA2; mismatch repair; CDKN2A; familial risk; multiple childhood tumors; Li-Fraumeni syndrome; TP53; adrenocortical carcinoma; choroid plexus tumors; rhabdomyosarcoma;

    Sammanfattning : The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. LÄS MER

  4. 4. Prostate cancer epidemiological studies

    Detta är en avhandling från Department of Oncology, Clinical Sciences, Lund University

    Författare :Henrik Grönberg; Per Lenner; Peter Iversen; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Epidemiology; Incidence; Age; Survival; Mortality; Familyhistory; Genetic factors; Body Mass Index; Diet;

    Sammanfattning : Prostate cancer is a large and increasing medical problem both in Sweden and in the rest of the developed world, with about 300.000 new cases diagnosed world wide annually. Despite the high incidence of this disease, little is known about the aetiology of prostate cancer. LÄS MER

  5. 5. Genetic characterization of malignant melanoma and breast cancer

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Göran B Jönsson; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; microarray; inherited breast cancer; Melanoma; linkage analysis; cancer; Cytologi; cancerology; onkologi;

    Sammanfattning : Malignant melanoma and breast cancer are common malignant diseases characterized by considerable heterogeneity with respect to genetics, histopathology, biology and clinical course. In breast cancer, two major susceptibility genes have been identified, BRCA1 and BRCA2, which account for a significant proportion of high-risk breast cancer families. LÄS MER