Sökning: "predictive modelling"

Visar resultat 16 - 20 av 156 avhandlingar innehållade orden predictive modelling.

  1. 16. Gas Metal Arc Melt Pool Modelling : Effect of welding position and electromagnetic force mode

    Författare :Pradip Aryal; Isabelle Choquet; Högskolan Väst; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gas metal arc welding; Gravitational force; Substrate orientation; Electromagnetic force modelling; Free surface deformation; Computational Fluid Dynamics; OpenFOAM; Gasmetallbågsvetsning; Gravitation; Svetsläge; Elektromagnetisk kraftmodellering; Smältytans rörelser; Computational Fluid Dynamics; OpenFOAM; Production Technology; Produktionsteknik;

    Sammanfattning : Gas metal arc is a high-efficiency and widely used heat source for metal processing applied predominantly in welding and additive manufacturing. In this study, it was applied to welding. LÄS MER

  3. 17. Reproducible Data Analysis in Drug Discovery with Scientific Workflows and the Semantic Web

    Författare :Samuel Lampa; Ola Spjuth; Roland Grafström; Konrad Hinsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Reproducibility; Scientific Workflow Management Systems; Workflows; Pipelines; Flow-based programming; Predictive modelling; Semantic Web; Linked Data; Semantic MediaWiki; MediaWiki; RDF; SPARQL; Golang; Reproducerbarhet; Arbetsflödeshanteringssystem; Flödesbaserad programmering; Prediktiv modellering; Semantiska webben; Länkade data; Go; Bioinformatics; Bioinformatik; Pharmacology; Farmakologi;

    Sammanfattning : The pharmaceutical industry is facing a research and development productivity crisis. At the same time we have access to more biological data than ever from recent advancements in high-throughput experimental methods. LÄS MER

  4. 18. Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes

    Författare :Steve Choy; Maria Kjellsson; Mats Karlsson; Willem de Winter; Andrea Mari; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; glucose homeostasis; insulin; type 2 diabetes; obesity; weight; visceral adipose tissue; HbA1c; non-linear mixed effects; modelling; disease progression; ZDSD rats; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by consistently high blood glucose, resulting from a combination of insulin resistance and reduced capacity of β-cells to secret insulin. While the exact causes of T2DM is yet unknown, obesity is known to be a major risk factor as well as co-morbidity for T2DM. LÄS MER

  5. 19. Models for Ordered Categorical Pharmacodynamic Data

    Författare :Per-Henrik Zingmark; Mats O Karlsson; E. Niclas Jonsson; France Mentré; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Pharmacodynamic; Modelling; Categorical data; NONMEM; Proportional odds model; Markov model; Differential drug effect model; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Sammanfattning : In drug development clinical trials are designed to investigate whether a new treatment is safe and has the desired effect on the disease in the target patient population. Categorical endpoints, for example different ranking scales or grading of adverse events, are commonly used to measure effects in the trials. LÄS MER

  7. 20. Methodological Studies on Models and Methods for Mixed-Effects Categorical Data Analysis

    Författare :Maria C. Kjellsson; Mats O. Karlsson; Siv Jönsson; Gordon Graham; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacodynamics; Categorical data; Markov model; Modelling; NONMEM; NLMIXED; Laplace; Gaussian quadrature; Back-Step Method; Proportional odds model; Differential odds model;

    Sammanfattning : Effects of drugs are in clinical trials often measured on categorical scales. These measurements are increasingly being analyzed using mixed-effects logistic regression. However, the experience with such analyzes is limited and only a few models are used. LÄS MER