Sökning: "non-linear mixed effects"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden non-linear mixed effects.

  1. 1. Methodological studies on non-linear mixed effects model building

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :E. Niclas Jonsson; Uppsala universitet.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Sammanfattning : Population analysis of pharmacokinetic/pharmacodynamic (PK/PD) data by the use of non-linear mixed effects modeling offers a number of benefits over traditional methods of analyzing this type of data. These benefits include the possibility to appropriately characterize the typical PK/PD behaviour in the population as well as the associated variability when only a few observations are available for each individual. LÄS MER

  2. 2. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design Pre-Clinical and Clinical Study Applications

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Charles Ernest II; Uppsala universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; population models; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). LÄS MER

  3. 3. Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Steve Choy; Uppsala universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; glucose homeostasis; insulin; type 2 diabetes; obesity; weight; visceral adipose tissue; HbA1c; non-linear mixed effects; modelling; disease progression; ZDSD rats; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by consistently high blood glucose, resulting from a combination of insulin resistance and reduced capacity of β-cells to secret insulin. While the exact causes of T2DM is yet unknown, obesity is known to be a major risk factor as well as co-morbidity for T2DM. LÄS MER

  4. 4. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Matts Kågedal; Uppsala universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PET; positron emission tomography; receptor occupancy; nonlinear mixed effects; NONMEM; optimal design; dose finding; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man. The aim of this thesis was to develop nonlinear mixed effects methods for estimation of the relationship between drug exposure and receptor occupancy for the two mGluR5 antagonists AZD9272 and AZD2066 and for the 5HT1B receptor antagonist AZD3783. LÄS MER

  5. 5. Improved Material Models for High Strength Steel

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Rikard Larsson; Linköpings universitet.; Linköpings universitet.; [2011]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Plastic anisotropy; non-linear strain paths; mixed isotropic-kinematic hardening; isotropic-distortional hardening; dynamic strain ageing; static strain ageing; marten- sitic transformation;

    Sammanfattning : The mechanical behaviour of the three advanced high strength steel grades, Docol 600DP, Docol 1200M and HyTens 1000, has been experimentally investigated under various types of deformation, and material models have been developed, which account for the experimentally observed behaviour.Two extensive experimental programmes have been conducted in this work. LÄS MER