Sökning: "poly A polymerase"

Visar resultat 16 - 20 av 34 avhandlingar innehållade orden poly A polymerase.

1. 16. Expression and regulation of Rad51 in human cells

   Författare :Jenny Flygare; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HsRad51 recombination; DNA repair; cell cycle; apoptosis; caspase-3; hybridization array;

   Sammanfattning : Double strand breaks (DSBs) can be caused by exogenous DNA damaging agents or by endogenous processes, and may lead to chromosomal breakage and rearrangement resulting in apoptosis or tumorigenesis. The repair of DSBs in higher eukaryotes is to a large extent accomplished by homologous recombination (HR), a process in which DNA from a complementary strand is used as a template for repair synthesis. LÄS MER

3. 17. Transcriptional Silencing in the Imprinted Igf2-H19 Loci: The Mystique of Epigenetics

   Författare :Vasudeva Ginjala; Andreas Paldi; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Imprinting; DNA methylation; IGF2-H19; CTCF; ZFPs; PARP; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Genetics; genetik;

   Sammanfattning : Genomic imprinting marks a subset of autosomal loci expressed in parent of origin-dependent monoallelic expression in a non-Mendelian fashion. To restore totipotency and to reset the imprint according to the sex of the individual, the mark must be erased during germline development. LÄS MER

4. 18. The mode of action of the radiosensitizing analogs metoclopramide and nicotinamide

   Författare :Anders Olsson; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medical instrumentation; metoclopramide; nicotinamide; apoptosis; radiosensitization; NAD; benzamide; DNA repair; Clinical physics; tomography; radiology; Klinisk fysiologi; radiologi; tomografi; medicinsk instrumentering;

   Sammanfattning : This thesis provides the first attempt to study the nicotinamides and benzamides from a mode of action point of veiw. Understanding the effects on DNA repair, cell cycle control (proliferation) and cell death from these agents and in combination with ionizing radiation, provides a new opportunity to logically develop better approaches to sensitize already existing therapies via for example induction of apoptosis or inhibition of DNA repair. LÄS MER

5. 19. Immunoregulation by mononuclear phagocytes. Mechanisms and clinical implications

   Författare :Ana Romero; Göteborgs universitet; []
   Nyckelord :;

   Sammanfattning : The cytotoxic effector lymphocytes of the immune system, the natural killer (NK) cells and the CD8+ T lymphocytes (CTL), have been ascribed a pivotal role in defense against malignancy. However, the function of these cells is frequently compromised, in particular at sites of malignant cell expansion. LÄS MER

7. 20. Molecular mechanisms and targets of new anticancer treatments

   Författare :Amirata Saei Dibavar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The work presented in this thesis is an effort to decipher and understand the mechanism of action (MOA) of anticancer agents by building on and complementing chemical proteomics methods. The backbone of the thesis relies on a recent method called Functional Identification of Target by Expression Proteomics (FITExP) developed in Zubarev lab, where drug induced proteomic signatures are analyzed in various cell lines and top differentially regulated proteins with consistent behavior are determined, among which the drug target and mechanistic proteins are usually present. LÄS MER