Sökning: "radiosensitization"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet radiosensitization.

  1. 1. Towards Personalized Cancer Therapy New Diagnostic Biomarkers and Radiosensitization Strategies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Diana Spiegelberg; Uppsala universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor targeting; radionuclide targeting; HSP90 inhibition; AT13387; radiosensitization; molecular imaging; combination treatment; EGFR; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : This thesis focuses on the evaluation of biomarkers for radio-immunodiagnostics and radio-immunotherapy and on radiosensitization strategies after HSP90 inhibition, as a step towards more personalized cancer medicine. There is a need to develop new tracers that target cancer-specific biomarkers to improve diagnostic imaging, as well as to combine treatment strategies to potentiate synergistic effects. LÄS MER

  2. 2. Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna-Karin Elf; Göteborgs universitet.; Gothenburg University.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroendocrine tumour; peptide receptor radionuclide therapy; somatostatin receptor 2 expression; radiosensitization; radioembolization; diffusion weighted imaging;

    Sammanfattning : ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, which are overexpressed on NET cells. PRRT results in symptom relief and often tumour control of NETs, but rarely cure. LÄS MER

  3. 3. ARCON in experimental and clinical radiotherapy

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ana Maria Rojas Callejas; Umeå universitet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; ARCON; tumours; normal tissues; radiosensitization; carbogen; nicotinamide; repair inhibition; therapeutic gain; rodents; humans; Onkologi; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; onkologi; Oncology;

    Sammanfattning : xHypoxia and repopulation of tumour clonogens are two important determinants of treatment outcome in radiotherapy. In general clinical evidence indicates that loco-regional control may be reduced with long overall treatment times and for tumours with low pre-treatment levels of oxygen. LÄS MER

  4. 4. Precision medicine and targeted therapy Turning the tables on cancer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anja Mortensen; Uppsala universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p53 cancers; PM2; radiosensitization; radio-immunotherapy; MDM2 X inhibition; combination therapy; targeted radionuclide therapy; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : An extended understanding of the molecular characteristics of cancer has led to a revolution within the field of precision medicine. This thesis explores the utilization of two targets for precision medicine, namely, CD44v6 and murine double-minute 2 and X (MDM2/X). LÄS MER

  5. 5. The mode of action of the radiosensitizing analogs metoclopramide and nicotinamide

    Detta är en avhandling från A Olsson, Molecular Ecogenetics, Wallenberg laboratory, Box 7031 220 07 Lund

    Författare :Anders Olsson; Lunds universitet.; Lund University.; [1997]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medical instrumentation; metoclopramide; nicotinamide; apoptosis; radiosensitization; NAD; benzamide; DNA repair; Clinical physics; tomography; radiology; Klinisk fysiologi; radiologi; tomografi; medicinsk instrumentering;

    Sammanfattning : This thesis provides the first attempt to study the nicotinamides and benzamides from a mode of action point of veiw. Understanding the effects on DNA repair, cell cycle control (proliferation) and cell death from these agents and in combination with ionizing radiation, provides a new opportunity to logically develop better approaches to sensitize already existing therapies via for example induction of apoptosis or inhibition of DNA repair. LÄS MER