Sökning: "Lund Wallenberg Neurocentrum"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Lund Wallenberg Neurocentrum.

1. 1. Gene therapy in epilepsy: neuropeptides and neurotrophic factors

   Författare :Irene Kanter Schlifke; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; neuropsychology; Neurology; piriform cortex; hippocampus; neuropsykologi; encapsulated cells; viral vectors; GDNF; galanin; epilepsy; gene therapy; neurofysiologi;

   Sammanfattning : Temporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach for treatment of TLE. LÄS MER

3. 2. Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia

   Författare :Michel Ferrand-Drake; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; neuronal death; calpain; caspase; mitochondrial permeability transition; necrosis; apoptosis; cerebral ischemia; hypoglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia Following prolonged disruption of blood flow to the central nervous system (CNS), or energy deprivation by other means, such as hypoglycemia, some cells will inevitably degenerate. It has been, and still is, the subject of considerable debate and intense research on brain ischemia, as to the mode of cell death, i. LÄS MER

4. 3. Ischemic and Hypoglycemic Brain Damage, Involvement of the Mitochondrial Permeability Transition Pore

   Författare :Hans Friberg; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitochondrial permeability transition pore; mitochondria; apoptosis; neuronal death; brain; ischemia; hypoglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : Brain damage from ischemia-reperfusion and hypoglycemia are major causes of morbidity and mortality. Therapeutic strategies include hypothermia, glutamate-receptor blockade, immunosuppression and lately treatment aiming at preserving mitochondrial integrity and function. LÄS MER

5. 4. Characterization of the perturbed differentiation in neuroblastoma, aided by the analysis of normal sympathetic nervous system development

   Författare :Carolina Gestblom; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; development; TrkA; apoptosis; proliferation; sympathetic nervous system; neuronal; paraganglia; neuroblastoma; chromaffin; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : Neuroblastoma is a pediatric tumor derived from cells in the sympathetic nervous system. In an attempt to explain the heterogeneous clinical behavior of neuroblastoma tumors, neuroblastomas have been characterized with regard to their degree of sympathetic differentiation. LÄS MER

7. 5. Changes in gene expression during delayed neuronal death after cerebral ischemia in the rat

   Författare :Fredrik Kamme; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; ischemia; brain; neuronal death; gene expression; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : After transient global cerebral ischemia, selected populations of neurons in the brain will die after a period of 2-3 days, a phenomenon termed delayed neuronal death. This is of clinical importance as delayed neuronal death has been found to occur in humans as well. LÄS MER