Sökning: "NAD"
Visar resultat 1 - 5 av 86 avhandlingar innehållade ordet NAD.
1. The mode of action of the radiosensitizing analogs metoclopramide and nicotinamide
Sammanfattning : This thesis provides the first attempt to study the nicotinamides and benzamides from a mode of action point of veiw. Understanding the effects on DNA repair, cell cycle control (proliferation) and cell death from these agents and in combination with ionizing radiation, provides a new opportunity to logically develop better approaches to sensitize already existing therapies via for example induction of apoptosis or inhibition of DNA repair. LÄS MER
2. Cellular targets of Pseudomonas aeruginosa toxin Exoenzyme S
Sammanfattning : Pseudomonas aeruginosa is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients. It uses a type III secretion dependent mechanism to translocate toxic effector proteins directly into the eukaryotic cell. LÄS MER
3. On the effects of Streptococcal NAD+-glycohydrolase and Streptolysin O on macrophages
Sammanfattning : SummaryThe human pathogen Streptococcus pyogenes (GAS) causes both superficial infections, such as strep throat, and invasive infections, such as necrotizing fasciitis, and is responsible for about half a million deaths each year. The number of GAS infections have increased since the 1980’s, due to the emergence of a M1T1 strain that has become widely disseminated. LÄS MER
4. PROBING NAD(P)H AVAILABILITY IN LIVING CELLS USING MINIATURIZED ELECTROCHEMICAL SYSTEMS
Sammanfattning : The work presented in this thesis demonstrates the application of electrochemical methods for probing the dynamics of cellular metabolism in prokaryotic and eukaryotic cells. The main part of the work has been done using genetically modified strains of yeast. Employing baker’s yeast, S. LÄS MER
5. Gene description, activity quantification and physiological responses of mitochondrial alternative NAD(P)H dehydrogenases
Sammanfattning : In addition to proton-pumping complex I, the plant respiratory chain contains type II NAD(P)H dehydrogenases. These extra enzymes do not pump protons and consequently do not contribute to the electrochemical proton gradient. LÄS MER