Sökning: "IGF2-H19"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet IGF2-H19.
1. Transcriptional Silencing in the Imprinted Igf2-H19 Loci: The Mystique of Epigenetics
Sammanfattning : Genomic imprinting marks a subset of autosomal loci expressed in parent of origin-dependent monoallelic expression in a non-Mendelian fashion. To restore totipotency and to reset the imprint according to the sex of the individual, the mark must be erased during germline development. LÄS MER
2. The Epigenetics of Gene Transcription and Higher Order Chromatin Conformation
Sammanfattning : It is becoming increasingly clear that long-range control of gene expression is mediated through direct physical interactions between genes and regulatory elements, either intra- or interchromosomally. In addition to transcriptional initiation, formation of active chromatin hubs seem to be crucial for increased transcriptional efficiency as well as insulation from neighbouring heterochromatic environment. LÄS MER
3. Differential microRNA and metabolic expressions in neuroendocrine and cervical carcinomas
Sammanfattning : MicroRNAs (miRNAs) are important regulators of many biological processes involved in cancer development and progression. However, the functional roles of miRNAs in some cancer types are still poorly understood. LÄS MER
4. Epigenetic Regulation of Genomic Imprinting and Higher Order Chromatin Conformation
Sammanfattning : The genetic information encoded by the DNA sequence, can be expressed in different ways. Genomic imprinting is an epigenetic phenomenon that results in monoallelic expression of imprinted genes in a parent of origin-dependent manner. Imprinted genes are frequently found in clusters and can share common regulatory elements. LÄS MER
5. Epigenetic Regulation of Higher Order Chromatin Conformations and Gene Transcription
Sammanfattning : Epigenetic states constitute heritable features of the chromatin to regulate when, where and how genes are expressed in the developing conceptus. A special case of epigenetic regulation, genomic imprinting, is defined as parent of origin-dependent monoallelic expression. LÄS MER