Sökning: "CTCF"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet CTCF.

  1. 1. CTCF and Epigenetic Regulation of the H19/Igf2 Locus

    Författare :Vinod Pant; Rolf Ohlsson; Rainer Reinkawitz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Imprinting; Chromatin; H19; Igf2; CTCF; Insulator; methylation; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : An overall coordination between the expressions of genes is required for the proper development of an individual. Although most genes are expressed from both the constituent alleles of the genome, a small subset of autosomal genes are preferentially expressed from only one of the parental alleles, a phenomenon known as genomic imprinting. LÄS MER

  3. 2. Chromatin Insulators and CTCF: Architects of Epigenetic States during Development

    Författare :Rituparna Mukhopadhyay; Rolf Ohlsson; Karim Malik; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; DNA methylation; CTCF; Chromatin insulators; Microarray; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : A controlled and efficient coordination of gene expression is the key for normal development of an organism. In mammals, a subset of autosomal genes is expressed monoallelically depending on the sex of the transmitting parent, a phenomenon known as genomic imprinting. LÄS MER

  4. 3. Epigenetic Regulation and Reprogramming of the H19 Imprinting Control Region

    Författare :Piero Mariano; Rolf Ohlsson; Karl Ekwall; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Imprinting; chromatin; H19; Igf2; CTCF; Insulator; methylation; Boris; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : The development of a new individual from the fertilized oocyte can ultimately be seen as the consequence of the establishment and maintenance of specific patterns of gene expression. Although regulation of gene activity occurs at different levels, cellular specialization and differentiation are the results of developmental cues that essentially take place at the transcriptional level. LÄS MER

  5. 4. Epigenetic Regulation of Genomic Imprinting and Higher Order Chromatin Conformation

    Författare :Gholamreza Tavoosidana; Rolf Ohlsson; Job Dekker; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Epigenetic; Imprinting; Chromatin; CTCF; H19 ICR; 4C; Utvecklingsbiologi; Biology; Biologi;

    Sammanfattning : The genetic information encoded by the DNA sequence, can be expressed in different ways. Genomic imprinting is an epigenetic phenomenon that results in monoallelic expression of imprinted genes in a parent of origin-dependent manner. Imprinted genes are frequently found in clusters and can share common regulatory elements. LÄS MER

  7. 5. Epigenetic Regulation of Replication Timing and Signal Transduction

    Författare :Rosita Bergström; Aristidis Moustakas; Carl-Henrik Heldin; Rolf Ohlsson; Alain Mauviel; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; Chromatin; CTCF; Epigenetics; Genomic Imprinting; H19; Id; Igf2; Insulator; Replication; Signal Transduction; Smad; TGF-β; Transcription; Cell- och molekylärbiologi;

    Sammanfattning : Upon fertilization the paternal and maternal genomes unite, giving rise to the embryo, with its unique genetic code. All cells in the human body are derived from the fertilized ovum: hence they all contain (with a few exceptions) the same genetic composition. LÄS MER