Sökning: "non-linear mixed effects"

Visar resultat 11 - 15 av 26 avhandlingar innehållade orden non-linear mixed effects.

  1. 11. Pharmacometric models to inform dose selection and study design : Applied in hemophilia and tuberculosis

    Författare :Alan Faraj; Ulrika S. H. Simonsson; Joakim Nyberg; Ron Mathot; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug development; pharmacometrics; pharmacokinetics; pharmacodynamics; non-linear mixed effect models; hemophilia; tuberculosis; dose selection; study design; pediatric extrapolation;

    Sammanfattning : While tuberculosis is a global pandemic, hemophilia is a rare disease which many have not heard of. Due to tuberculosis mainly being a problem in developing countries and hemophilia being a rare disease, they are not as heard of as other diseases such as cancer or metabolic diseases which are on the rise in Western societies. LÄS MER

  3. 12. Dynamic single-cell modelling of nutrient signalling in budding yeast

    Författare :Sebastian Persson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nutrient signalling; single-cell; mixed-effects models; stochastic dynamic models; Bayesian inference;

    Sammanfattning : To survive in environments with constantly changing nutrient levels the bud- ding yeast Saccharomyces cerevisiae has a sophisticated nutrient sensing system. A central component of this system is the SNF1 signalling pathway, which primarily helps yeast adapt to glucose limited conditions. LÄS MER

  4. 13. Finite element procedures for crack path prediction in multi-axial fatigue

    Författare :Dimosthenis Floros; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Fracture mechanics; Configurational forces; Mixed-mode; Numerical simulation; Rolling contact fatigue; Plasticity;

    Sammanfattning : Rolling Contact Fatigue (RCF) cracks in rails are among the most detrimental railway track defects regarding reliability and cost. The cracks typically grow in shear mode up to a certain length at which they might arrest or kink into a more tensile-driven growth. LÄS MER

  5. 14. Optimal (Adaptive) Design and Estimation Performance in Pharmacometric Modelling

    Författare :Alan Maloney; Ulrika Simonsson; Mats Karlsson; Andy Grieve; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phase II; dose response; optimal design; adaptive design; exposure response; count data;

    Sammanfattning : The pharmaceutical industry now recognises the importance of the newly defined discipline of pharmacometrics. Pharmacometrics uses mathematical models to describe and then predict the performance of new drugs in clinical development. LÄS MER

  7. 15. Optimization of first-line anti-tuberculosis therapy in patients co-infected with HIV

    Författare :Jesper Sundell; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tuberculosis; HIV; Pharmacokinetics; Pharmacogenetics; LC-MS MS; Individualized therapy;

    Sammanfattning : Every year over one million people die from tuberculosis. People infected with HIV are significantly more vulnerable to tuberculosis, which is the leading cause of HIV-associated death. The first-line treatment for tuberculosis consists of rifampicin, isoniazid, pyrazinamide and ethambutol. LÄS MER