Sökning: "lipopolysaccharides"

Visar resultat 1 - 5 av 38 avhandlingar innehållade ordet lipopolysaccharides.

  1. 1. Mixed Effects Modelling and Optimal Design of TNFα Response in LPS Challenge Studies - Methods and Applications in Drug Discovery

    Författare :Julia Larsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pharmacodynamics; pharmacokinetics; non-linear mixed effects modelling; lipopolysaccharides; tumour necrosis factor alpha; optimal design;

    Sammanfattning : ''Endotoxin and mycoplasma are Nature’s darkest secrets. If they are ever solved, Hell itself will open.'' - Lewis Thomas* Endotoxin, or lipopolysaccharides (LPS), are heterogeneous components from the cell wall of Gram-Negative bacteria and a common challenger in the field of drug discovery. LÄS MER

  3. 2. Exploring the structure of oligo- and polysaccharides : Synthesis and NMR spectroscopy studies

    Författare :Hanna Jonsson; Göran Widmalm; Antonio Molinaro; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; NMR spectroscopy; synthesis; lipopolysaccharides; conformational studies; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : A deeper understanding of the diversity of carbohydrates and the many applications of oligo- and polysaccharides found in nature are of high interest. Many of the processes involving carbohydrates affect our everyday life. This thesis is based on six papers all contributing to an extended perspective of carbohydrate property and functionality. LÄS MER

  4. 3. Monoclonal antibodies against Haemophilus lipopolysaccharides

    Författare :Silvia Borrelli; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Haemophilus influenzae Haemophilus ducreyi Monoclonal antibody MAh :Bacterial lipopolysaccharide LPS Antigen detection Epitopes Epitope accessibility:Immunochemistry EIA Specificity.;

    Sammanfattning : The genus Haemophilus comprises a group of gram-negative bacteria with fastidious growth requirements. Among the Haemophilus species, H. influenzae and H. ducreyi are the most important in human medicine. LÄS MER

  5. 4. Role of Neuroinflammation in Parkinson's Disease and Related Disorders

    Författare :Edoardo Brandi; Neural plasticitet och reparation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha synuclein; Preformed fibrils; Microglia; Astrocyte; Neuroinflammation; Lipopolysaccharides; Parkinson Disease; Lewy Body Dementia; Multiple system atrophy; Synucleinopathies;

    Sammanfattning : Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates, progressive neurodegeneration, and neuroinflammation. Alpha-synuclein (a-syn) is the principal component of intracellular aggregates and can be modified by several mutations and post-translational modifications (PTMs), which can alter the protein structure affecting its aggregation, toxicity, and ability to spread. LÄS MER

  7. 5. Studies on some Salmonella lipopolysaccharides

    Författare :Carl Gustaf Hellerqvist; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : .... LÄS MER