Sökning: "total score analysis"

Visar resultat 1 - 5 av 164 avhandlingar innehållade orden total score analysis.

1. 1. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data

   Författare :Gustaf Wellhagen; Maria C. Kjellsson; Bengt Hamrén; Per Olsson Gisleskog; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; modelling; non-linear mixed effects modelling; composite scale data; total score data; total score analysis; precision prediction; bounded integer; bounded integer model; IRT-informed total score analysis; item response theory-informed; mixed models for repeated measures; MMRM; dose-response; dose-response mixed models for repeated measures; DR-MMRM; HbA1c models; fit-for-purpose analysis; clinical trial analysis; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. LÄS MER

3. 2. Gait and motion analysis of hip arthroplasty. Validity, reliability and longterm results

   Författare :Roland Zügner; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gait analysis; Hip arthroplasty; Kinematics; Radiostereometric analysis; Hip osteoarthritis;

   Sammanfattning : Introduction: Walking is one of the most fundamental activities of daily living in humans, when the hip joints transfer power between the lower extremities and the pelvis. Hip osteoarthritis (OA) will more or less influence this function and is increasing in an ageing population. LÄS MER

4. 3. Anatomic anterior cruciate ligament reconstruction - aspects of surgical technique

   Författare :Neel Desai; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Knee; Anterior cruciate ligament; Anatomic; Double-bundle; Single-bundle; Laxity; Register; AARSC; Score; Graft failure; Revision; Outcome;

   Sammanfattning : Anatomic anterior cruciate ligament (ACL) reconstruction is a concept that has gained in interest and it aims to more effectively restore native ACL anatomy and function. Despite extensive research on the topic, the optimal surgical technique to accomplish this is still the subject of debate. LÄS MER

5. 4. Metabolic factors and bladder cancer risk and mortality. Studies to approach causal associations and interactions with smoking and genetic variants

   Författare :Stanley Teleka; Registerbaserad epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bladder cancer; metabolic factors; Association; Interaction; Blood pressure; BMI; statistical analysis; Mendelian Randomization Analysis;

   Sammanfattning : Urothelial bladder cancer (BC) is one of the most common cancers in developed countries. It has one of the highest recurrence rates among solid tumors, resulting in regular treatment and follow-up, making it one of the most expensive cancers to treat, and a significant public health burden. LÄS MER

7. 5. Improved statistical methodology for high-throughput omics data analysis

   Författare :Wenjiang Deng; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of sequencing techniques. LÄS MER