Sökning: "non-linear mixed effects"

Visar resultat 16 - 20 av 26 avhandlingar innehållade orden non-linear mixed effects.

1. 16. Pharmacometric Models in Anesthesia and Analgesia

   Författare :Marcus Björnsson; Ulrika Simonsson; Mats Karlsson; Leonid Gibiansky; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; Anesthesia; Analgesia; Dropout; NONMEM; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Sammanfattning : Modeling is a valuable tool in drug development, to support decision making, improving study design, and aid in regulatory approval and labeling. This thesis describes the development of pharmacometric models for drugs used in anesthesia and analgesia. LÄS MER

3. 17. Models for Ordered Categorical Pharmacodynamic Data

   Författare :Per-Henrik Zingmark; Mats O Karlsson; E. Niclas Jonsson; France Mentré; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Pharmacodynamic; Modelling; Categorical data; NONMEM; Proportional odds model; Markov model; Differential drug effect model; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

   Sammanfattning : In drug development clinical trials are designed to investigate whether a new treatment is safe and has the desired effect on the disease in the target patient population. Categorical endpoints, for example different ranking scales or grading of adverse events, are commonly used to measure effects in the trials. LÄS MER

4. 18. Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients

   Författare :Karin Lindahl; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hepatits C; ribavirin; pharmacokinetics; renal function; plasma concentration; anaemia; population pharmacokinetic analysis; peginterferon; sustained viral response;

   Sammanfattning : Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available are not optimal either regarding cure of disease or risk of side effects. LÄS MER

5. 19. Accelerating Monte Carlo methods for Bayesian inference in dynamical models

   Författare :Johan Dahlin; Thomas B. Schön; Fredrik Lindsten; Richard Everitt; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Computational statistics; Monte Carlo; Markov chains; Particle filters; Machine learning; Bayesian optimisation; Approximate Bayesian Computations; Gaussian processes; Particle Metropolis-Hastings; Approximate inference; Pseudo-marginal methods;

   Sammanfattning : Making decisions and predictions from noisy observations are two important and challenging problems in many areas of society. Some examples of applications are recommendation systems for online shopping and streaming services, connecting genes with certain diseases and modelling climate change. LÄS MER

7. 20. Effective vibro-acoustical modelling of rubber isolators

   Författare :Michael Coja; Leif Kari; Wolfgang Kropp; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Applied mechanics; Rubber isolator; Bush mounting; Dynamic stiffness; Waveguide; Fractional derivatives; Mode-matching; Pre-compressed; Prestrain; Preload; Predeformation; Viscoelasticity; Dispersion; Teknisk mekanik; Engineering mechanics; Teknisk mekanik;

   Sammanfattning : This thesis, gathering four papers, concerns the enhancement in understanding and modelling of the audible dynamic stiffness of vibration rubber isolators including experimental measurements. Paper A studies the performances of three different types of vibration isolator using an indirect measurement technique to estimate the blocked dynamic transfer stiffness of each specimen. LÄS MER