Sökning: "in vitro modeller"

Visar resultat 1 - 5 av 34 avhandlingar innehållade orden in vitro modeller.

  1. 1. In silico tools in risk assessment : of industrial chemicals in general and non-dioxin-like PCBs in particular

    Författare :Mia Stenberg; Patrik Andersson; Miriam Jacobs; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; industrial chemicals; in silico tools; molecular descriptors; non-dioxin-like PCBs; partial least-squares PLS ; principal component analysis PCA ; quantitative structure-activity relationship QSAR ; REACH; risk assessment RA ; statistical molecular design; structure-activity relationship SAR ;

    Sammanfattning : Industrial chemicals in European Union produced or imported in volumes above 1 tonne annually, necessitate a registration within REACH. A common problem, concerning these chemicals, is deficient information and lack of data for assessing the hazards posed to human health and the environment. LÄS MER

  3. 2. Ischemic Cell Death in the CNS - applications of a new in vitro model

    Författare :Tobias Cronberg; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Neurologi; Neurology; astrocyte; stroke; adenosine; hyperglycaemia; glucose; free radicals; calcium; in vitro; brain ischemia; slice; neuropsychology; neurofysiologi; neurophysiology;

    Sammanfattning : Ischemic brain damage is a common cause of death and disability. A global ischemic insult is usually the result of a transient cardiac arrest while occlusion of cerebral blood vessels leads to focal ischemic lesions, commonly termed stroke. LÄS MER

  4. 3. Spider Silk Nanostructuring and its Applications for Tissue Engineering

    Författare :Linnea Gustafsson; Wouter van der Wijngaart; David Kaplan; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; recombinant spider silk; nanostructures; microstrucutres; nanowires; nanochains; nanodisks; nanomembranes; tissue engineering; in-vitro models; medical technology; health technology; nanomedicine; rekombinant spindelsilke; nanostrukturer; mikrostrukturer; nanotrådar; nanokedjor; nanodiskar; nanomembran; vävnadsteknik; in vitro-modeller; medicinsk teknik; hälsoteknik; nanomedicin; Electrical Engineering; Elektro- och systemteknik;

    Sammanfattning : This thesis introduces new ways to produce micro-and nanostructures of recombinant spider silk and explores ways to characterize their topography, mechanical properties, cell compatibility, and permeability. The suitability of the formed structures for applications within tissue engineering, primarily in vitro tissue modeling, is also investigated. LÄS MER

  5. 4. Factors influencing nerve growth in situ and in vitro

    Författare :Helena Jerregård; Mårten Risling; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Bakgranden till denna doktorsavhaodling är den problematik som uppstår efter en perifer nervskada, roreträdesvis i relation till handen eftersom den har så stor betydelse i vårt dagliga liv. En haod utan känsel fungerar dåligt och än sänne fungerar en handprotes. LÄS MER

  7. 5. Recreating the microenvironment of the neurovascular unit

    Författare :Isabelle Matthiesen; Anna Herland; Thomas E. Winkler; Stéphanie Descroix; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microphysiological systems; neurovascular unit; induced pluripotent stem cells; extracellular matrix; hydrogels; in vitro models; mikrofysiologiska system; neurovaskulära enheten; inducerade pluripotenta stamceller; extracellulära matrisen; hydrogeler; in vitro modeller; Bioteknologi; Biotechnology;

    Sammanfattning : The neurovascular unit (NVU) comprises the blood-brain-barrier (BBB) and its surrounding astrocytes, pericytes and neurons that are embedded in the extracellular matrix (ECM). As the main function of the BBB is to protect the brain from inlet of pathogens and toxins, the specialized endothelial cells that keep the barrier tight will also hinder the passage of pharmaceuticals. LÄS MER