Sökning: "microphysiological systems"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden microphysiological systems.
1. Organic Electronics and Microphysiological Systems to Interface, Monitor, and Model Biology
Sammanfattning : Biological processes in the human body are regulated through complex and precise arrangements of cell structures and their interactions. In vivo models serve as the most accurate choice for biological studies to understand these processes. However, they are costly, time-consuming, and raise ethical issues. LÄS MER
2. Human iPSC-based models of theCNS: attaining cellular biofidelitythrough conventional and advancedculture systems
Sammanfattning : Brain development is a highly orchestrated process that entails changes in microenvironmental cues and growth factor gradients, which set the tempo for proper development of the rudimentary structures of the brain and the generation of neurons,astrocytes, and oligodendrocytes. Another intricate feature of the brain is the bloodbrain barrier (BBB). LÄS MER
3. Fabrication advances of microvasculature models on-chip
Sammanfattning : Despite the technological advances of the last decades, drug development remains a lengthy and costly process with uncertainties still associated with the poor predictive power of the in vitro and animal models. To address this limitation, microphysiological systems have been introduced in an attempt to increase the biological relevance of in vitro devices. LÄS MER
4. Recreating the microenvironment of the neurovascular unit
Sammanfattning : The neurovascular unit (NVU) comprises the blood-brain-barrier (BBB) and its surrounding astrocytes, pericytes and neurons that are embedded in the extracellular matrix (ECM). As the main function of the BBB is to protect the brain from inlet of pathogens and toxins, the specialized endothelial cells that keep the barrier tight will also hinder the passage of pharmaceuticals. LÄS MER
5. Novel in vitro systems elucidating metabolic health and disease
Sammanfattning : The convoluted nature of biology warrants improved models that further insights into health and disease. Bioengineered features and platforms allow the modulation and study of a range of biological phenomena. LÄS MER
