Sökning: "glycosaminoglycans"

Visar resultat 11 - 15 av 76 avhandlingar innehållade ordet glycosaminoglycans.

  1. 11. Functional and molecular aspects of the glomerular barrier

    Författare :Anna Björnson Granqvist; Göteborgs universitet; []
    Nyckelord :glomerular endothelium; glycocalyx; podocyte; proteoglycan; glycosaminoglycans; nephrotic syndrome;

    Sammanfattning : The kidneys are crucial for maintaining a normal salt-water balance in the body, which is a prerequisite for life. They do that by filtering 180 liters of plasma per day across the highly permselective glomerular barrier and reabsorbing 99 % of the filtrate. LÄS MER

  3. 12. The expression and regulation of hyaluronan synthases and their role in glycosaminoglycan synthesis

    Författare :Jonas Brinck; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; hyaluronan; glycosaminoglycans; CD44; growth factors; UDP-glucose dehydrogenase; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : The glycosaminoglycan hyaluronan is an essential component of the extracellular matrix in all higher organisms, affecting cellular processes such as migration, proliferation and differentiation. Hyaluronan is synthesized by a plasma membrane bound hyaluronan synthase (HAS) which exists in three genetic isoforms. LÄS MER

  4. 13. Properties of the glomerular endothelial cell surface layer in vitro and in vivo

    Författare :Vincent Fridén; Göteborgs universitet; []
    Nyckelord :Glomerular filtration; Glomerular endothelial cell surface layer; Proteinuria; Proteoglycans; glycocalyx; glycosaminoglycans; glomerular endothelial cells; permselectivity and glomerular endothelial cell coat;

    Sammanfattning : A healthy kidney produces final urine that is practically devoid of proteins and other physiologically important solutes. Tremendous amounts of fluid are filtered every day through the glomerular filtration barrier which is the actual sieving site in the kidney. LÄS MER

  5. 14. Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons

    Författare :Zuzanna Kurowska; Neural plasticitet och reparation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LUHMES cells; substantia nigra pars compacta; microarray; heparan sulphate 3-O-sulfotransferase; neurocan; midbrain dopaminergic neurons; grafting; embryonic stem cells; proteoglycans; glycosaminoglycans; Nogo-A; cell replacement therapy; Parkinson’s disease;

    Sammanfattning : Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. LÄS MER

  7. 15. Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans

    Författare :Mariam Rodríguez-Lee; Göteborgs universitet; []
    Nyckelord :proteoglycans; glycosaminoglycans; fatty acids; smooth muscle cells; hepatocytes; LDL binding; remnant clearance; insulin resistance; type 2 diabetes;

    Sammanfattning : Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins (LDL) in the intima by chondroitin sulfate (CS)-rich proteoglycans (PG). LÄS MER