Visar resultat 1 - 5 av 133 avhandlingar innehållade ordet proteoglycans.
Sammanfattning : Summary of PhD thesis in biochemistry (physiological chemistry). (The 6 papers were cited 628 times 1974-2004.).. LÄS MER
2. Effects of Endogenous and Exogenous Hormones on the Female Breast : With Special Reference to the Expression of Proteoglycans
Sammanfattning : This thesis aims to study the effects of endogenous and exogenous hormones and mammographic breast density (BD) on cellular markers in non-cancerous female breast tissue. Women on the waiting list for breast reduction plastic surgery were recruited (n = 79), and randomized to 2 months of hormone therapy or no therapy before surgery. LÄS MER
Sammanfattning : Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins (LDL) in the intima by chondroitin sulfate (CS)-rich proteoglycans (PG). LÄS MER
4. Proteoglycans, group IIA phospholipase A2, and lipoproteins.Potential involvement in atherogenesis
Sammanfattning : Atherosclerosis is a multifactorial complex disease characterized by a focal accumulation of ApoB-100 containing lipoproteins, extracellular matrix (ECM), and cells in the arterial intima accompanied by an inflammatory reaction. In vivo and in vitro data supports the hypothesis that sulfated extracellular proteoglycans may be responsible for the selective retention of low density lipoproteins (LDL) in the arterial wall. LÄS MER
Sammanfattning : A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible to modification and uptake by resident macrophages that are found in hypoxic sites in atherosclerotic lesions (with oxygen levels below 1%). LÄS MER