Sökning: "glycosaminoglycans"

Visar resultat 6 - 10 av 76 avhandlingar innehållade ordet glycosaminoglycans.

  1. 6. The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis

    Författare :Annika Asplund; Göteborgs universitet; []
    Nyckelord :atherosclerosis; proteoglycans; glycosaminoglycans; macrophages; hypoxia; hypoxia-inducible transcription factor; LDL binding; cell motility;

    Sammanfattning : A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible to modification and uptake by resident macrophages that are found in hypoxic sites in atherosclerotic lesions (with oxygen levels below 1%). LÄS MER

  3. 7. Studies of Glycosaminoglycan Interactions - Surface Immobilization Strategies and Biosensing Applications

    Författare :Noomi Altgärde; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; glycosaminoglycans; interaction studies; growth factor; QCM-D; virus glycoprotein; SPR; surface immobilization;

    Sammanfattning : Many important biological functions of glycosaminoglycans (GAGs) have been highlighted in research literature during recent years. GAGs often serve as function-bearing structural elements in the extracellular matrix (ECM), but are also constituents of the cell membrane. GAGs take part in various biological mechanisms, e.g. LÄS MER

  4. 8. QCM-D – with focus on biosensing in biomolecular and cellular systems

    Författare :Erik Nilebäck; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; QCM-D; biomolecular interactions; cell-surface interaction; glycosaminoglycans; viscoelasticity; cell morphology; Quartz crystal microbalance with dissipation monitoring; surface chemistry; protein conformation;

    Sammanfattning : The high degree of complexity in biological systems is being investigated in greater and greater detail by increasingly sophisticated sensing approaches. The quartz crystal microbalance with dissipation monitoring (QCM-D) technique stands out in this context, by probing the viscoelastic properties at interfaces. LÄS MER

  5. 9. Virus-cell membrane interactions - Binding studies of Herpes Simplex Virus using surface-sensitive techniques

    Författare :Nadia Peerboom; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TIRF microscopy; single particle tracking; binding kinetics; glycosaminoglycans; herpes simplex virus;

    Sammanfattning : Viruses are parasites capable of infecting all forms of life. They lack the ability to replicate by themselves and therefore hijack the replication machinery of cells to produce new viral copies, called virions. LÄS MER

  7. 10. Articular cartilage proteoglycan biosynthesis and sulfation

    Författare :Chengjuan Qu; Mikko Lammi; Heikki Helminen; Juha Töyräs; Anna-Marja Säämänen; Finland Kuopio University of Kuopio Anatomy Department of Biomedicine; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cartilage; Chondrocytes metabolism; Chondroitin sulfates; Glycosaminoglycans; Osteoarthritis; Proteoglycans; Glucosamine; Sulfation; Biochemistry; biokemi; cellforskning; cell research; Orthopaedics; ortopedi;

    Sammanfattning : Glucosamine (GlcN) and glucosamine sulfate (GS) have been used to treat the patients with osteoarthritis(OA) as a disease-modifying agent. Previousin vitro studies have focused on the effects of GlcN or GSon cartilage metabolism, whereas in vivo studies have investigated their potential for the treatment of OA. LÄS MER